New Articles
Chapter 1. Introduction
Chapter 2. Background
Chapter 3. Linkers for Combinatorial Synthesis
3.1.1. Convenient Method for Preparing Polystyrene Having beta-Hydroxy Group: Its Application to the Synthesis of Polyethylene Glycol-Grafted Polystyrene Resin Park, B.; Lee, H.; Ryoo, S.; Lee, Y. Tetrahedron Lett. 1997, 38, 591-594.
3.1.2. Solid-Phase Dendrimer Synthesis and the Generation of Super-High_Loading Resin Beads for Combinatorial Chemistry Swali, V.; Wells, N. J.; Langley, G. J.; Bradley, M. J. Org. Chem. 1997, 62, 4902-4903.
3.1.3. Molecular Diversity of Novel Amino Acid Based Dendrimers Mulders, S. J. E.; Brouwer, A. J.; Liskamp, R. M. J. Tetrahedron Lett. 1997, 38, 3085-3088.
3.1.4. Functional Polymers from (Vinyl)polystyrene. Short Routes to Binding Functional Groups to Polystyrene Resin through a Dimethylene Spacer: Bromine, Sulfur, Phosphorus, Silicon, Hydrogen, Boron, and Oxygen Stranix, B. R.; Gao, J. P.; Barghi, R.; Salha, J.; Darling, G. D. J. Org. Chem. 1997, 62, 8987-8993.
3.1.5. Efficient Synthesis of Bromoacetylated Wang Resin Nouvet, A.; Lamaty, F.; Lazaro, R. Tetrahedron Lett. 1998, 39, 3469-3470.
3.1.6. A Reinvestigation of the Preparation, Properties, and Applications of Aminomethyl and 4-Methylbenzhydrylamine Polystyrene Resins Adams, J. H.; Cook, R. M.; Hudson, D.; Jammalamadaka, V.; Lyttle, M. H.; Songster, M. F. J. Org. Chem. 1998, 63, 3706-3716.
3.1.7. PEGA Supports for Combinatorial Peptide Synthesis and Solid-Phase Enzymatic Library Assays Renil, M.; Ferreras, M.; Delaisse, J. M.; Foged, N. T.; Meldal, M. J. Peptide Sci. 1998, 4, 195-210.
3.1.8. Polymer Backbone Disassembly: Polymerisable Templates and Vanishing Supports in High Loading Parallel Synthesis Ball, C. P.; Barrett, A. G. M.; Poitout, L. F.; Smith, M. L.; Thorn, Z. E. Chem. Comm. 1998, 2453-2454.
3.1.9. Preparation, Structure and Morphology of Polymer Supports Sherrington, D. C. Chem. Comm. 1998, 2275-2286.
3.1.10. Soluble Supports Tailored for Organic Synthesis: Parallel Polymer Synthesis via Sequential Normal/Living Free Radical Processes Gravert, D. J.; Datta, A.; Wentworth, P.; Janda, K. D. J. Am. Chem. Soc. 1998, 120, 9481-9495.
3.1.11. A Measure of Solvent Effects on Swelling of Resins for Solid Phase Organic Synthesis Santini, R.; Griffith, M. C.; Qi, M. Tetrahedron Lett. 1998, 39, 8951-8954.
3.1.12. Cleavage and Analysis of Material from Single Resin Beads Wells, N. J.; Davies, M.; Bradley, M. J. Org. Chem. 1998, 63, 6430-6431.
3.1.13. Polymeric Supports for Solid Phase Synthesis Labadie, J. W. Curr. Opin. Chem. Biol. 1998, 2, 346-352.
3.1.14. Polystyrene Grafted Fluoropolymer MicroTubes: New Supports for Solid-Phase Organic Synthesis with Useful Performance at High Temperature Zhao, C.; Shi, S.; Mir, D.; Hurst, D.; Li, R.; Xiao, X. Lillig, J.; Czarnik, A. W. J. Combinatorial Chemistry 1999, 1, 1, 91-95.
3.1.15. On the Development of New Poly(styrene-oxyethylene) Graft Copolymer Resin Supports for Solid-Phase Organic Synthesis Gooding, O. W.; Baudart, S.; Deegan, T. L.; Heisler, K.; Labadie, J. W.; Newcomb, W. S.; Porco, J. A.; van Eikeren, P. J. Combinatorial Chemistry 1999, 1, 1, 113-122.
3.1.16. New high loading paramagnetic support for solid phase organic chemistry Sucholeiki, I.; Perez, J. M.Tetrahedron Lett. 1999,40(18), 3531-3534.
3.1.17. Resin-bound dendrimers as high loading supports for solid phase chemistry A. Mahajan, S. R. Chhabra, W. C. Chan, Tetrahedron Lett. 1999, 40(26), 4909-4912.
3.1.18. Matrix Assisted Synthetic Transformations: A Mosaic of Diverse Contributions. I. The Pattern Emerges Hudson, D.; J. Combinatorial Chemistry 1999, 1, 5, 333-360.
3.1.19. SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase Rademann, J., Grotli, M., Meldal, M., Bock, K. J. Am. Chem. Soc.; 1999; 121(23); 5459-5466.
3.1.20. Polymer discs - an alternative support format for solid phase synthesis N. Hird, I. Hughes, D. Hunter, M. G. J. T. Morrison, D. C. Sherrington, L. Stevenson Tetrahedron 1999, 55(31), 9575-9584.
3.1.21. New supports for solid-phase organic synthesis: development of polystyrene resins containing tetrahydrofuran derived cross-linkers P. H. Toy, K. D. Janda Tetrahedron Lett. 1999, 40(35), 6329-6332.
3.1.22. Functional polymers from (vinyl)polystyrene: Recyclable polymer-supported organosilicon protecting groups for solid-phase synthesis Stranix, B.R., Liu, H.Q., & Darling, G.D. J. Org. Chem. 1997, 62, 6183-6186.
3.1.23. A simple method for the generation of chloromethyl polystyrene on the Multipin™ solid support Bui, C. T.; Maeji, N. J.; Rasoul, F.; Bray, A. M. Tetrahedron Lett. 1999, 40(29), 5383 -5386.
3.2. Linkers for Carboxylic Acids
3.2.1. Calcium-Promoted Hydrolysis of N-Acylureas Allows Mild Release of Peptides Anchored with the Dpr(Phoc) Linker to Hydrophilic Resins Pascal, R.; Sola, R. Tetrahedron Lett. 1997, 38, 4549-4552.
3.2.2. Model Studies for New o-Nitrobenzyl Photolabile Linkers: Substituent Effects on the Rates of Photochemical Cleavage Holmes, C. P. J. Org. Chem. 1997, 62, 2370-2380.
3.2.3. New Fluoride-Labile Linkers for Solid-Phase Organic Synthesis Routledge, A.; Stock, T.; Flitsch, S. L.; Turner, N. J. Tetrahedron Lett. 1997, 38, 8287-8290.
3.2.4. New Synthesis of SASRIN Resin Katritzky, A. R.; Toader, D.; Watson, K.; Kiely, J. S. Tetrahedron Lett. 1997, 38,7849-7850.
3.2.5. An Improved Synthesis and Selective Coupling of a Hydroxy Based Photolabile Linker for Solid Phase Organic Synthesis Whitehouse, D. L.; Savinov, S. N.; Austin, D. J. Tetrahedron Lett. 1997, 38, 7851-7852.
3.2.6. Facile Solid Phase Synthesis of an Activated Diazo Linker Bhalay, G.; Dunstan, A. R. Tetrahedron Lett. 1998, 39, 7803-7806.
3.2.7. The Use of Trichloroacetamide-activated Resin for Ester Formation Phoon, C. W.; Oliver, S. F.; Abell, C. Tetrahedron Lett. 1998, 39, 7959-7962.
3.2.8. An Alkanesulfonamide "Safety-Catch" Linker for Solid-Phase Synthesis Backes, B. J.; Ellman, J. A. J. Org. Chem. 1999, 64, 7, 2322-2330.
3.2.9. HYCRON, an Allylic Anchor for High-Efficiency Solid Phase Synthesis of Protected Peptides and Glycopeptides O. Seitz, H. Kunz J.Org.Chem. 1997, 62, 813-826.
3.2.10. A Novel Resin Linker for Solid-Phase Peptide Synthesis Which Can Be Cleaved Using Two Sequential Mild Reactions A. Zheng, D. Shan, X. Shi, B. Wang J. Org. Chem. 1999; 64(20), 7459-7466.
3.2.11. The pivaloylglycol anchor group: A new platform for a photolabile linker in solid-phase synthesis Peukert, S., Giese, B. J. Org. Chem. 1998, 63, 9045-9051.
3.3.1. Preparation of Acid-labile Resins with Halide Linkers and their Utility in Solid Phase Organic Synthesis Ngu, K.; Patel, D. V. Tetrahedron Lett. 1997, 38, 973-976.
3.3.2. 9-Hydroxy-9-(4-carboxyphenyl)xanthene-A New Linker for the Synthesis of Peptide Amides Henkel, B.; Zeng, W.; Bayer, E. Tetrahedron Lett. 1997, 38, 3511-3512.
3.3.3. Use of Halomethyl Resins to Immobilize Amines: An Efficient Method for Synthesis of Sulfonamides and Amides on a Solid Support Raju, B.; Kogan, T. P. Tetrahedron Lett. 1997, 38, 4965-4968.
3.3.4. Secondary Amide-based Linkers for Solid Phase Organic Synthesis Swayze, E. E. Tetrahedron Lett. 1997, 38, 8465-8468.
3.3.5. Solid Phase Synthesis of Sec-Amides and Removal from the Polymeric Support Under Mild Conditions Sarantakis, D.; Bicksler, J. J. Tetrahedron Lett. 1997, 38, 7325-7328.
3.3.6. AMEBA: An Acid Sensitive Aldehyde Resin for Solid Phase Synthesis Fivush, A. M.; Willson, T. M. Tetrahedron Lett. 1997, 38, 7151-7154.
3.3.7. Indole Resin: a Versatile New Support for the Solid-Phase Synthesis of Organic Molecules Estep, K. G.; Neipp, C. E.; Stephens Stramiello, L. M.; Adam, M. D.; Allen, M. P.; Robinson, S.; Roskamp, E. J. J. Org. Chem. 1998, 63, 5300-5301.
3.3.8. An Acid- and Base-Stable o-Nitrobenzyl Photolabile Linker for Solid Phase Organic Synthesis Sternson, S. M.; Schreiber, S. L. Tetrahedron Lett. 1998, 39, 7451-7454.
3.3.9. A Backbone Linker for Boc-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1 Bourne, G. T.; Meutermans, W. D. F.; Alewood, P. F.; McGeary, R. P.; Scanlon, M.; Watson, A. A.; Smythe, M. L. J. Org. Chem. 1999, 64, 3095-3101.
3.3.10. Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the MultipinTM support C. T. Bui, A. M. Bray, F. Ercole, Y. Pham, F. A. Rasoul, N. J. Maeji, Tetrahedron Lett. 1999,40(17), 3471-3474.
3.3.11. Backbone Amide Linker (BAL) Strategy for Solid-Phase Synthesis of C-Terminal-Modified and Cyclic Peptides K. J. Jensen, J. Alsina, M. F. Songster, J. Vágner, F. Albericio, G. Barany J. Am. Chem. Soc. 1998, 120, 5441-5452.
3.3.12. The development of solid phase protocols for a backbone amide linker and its application to the Boc-based assembly of linear peptides G. T. Bourne, W. D. F. Meutermans, M. L. Smythe Tetrahedron Lett., 1999, 40, 7271 -7274.
3.3.13. Six new photolabile linkers for solid phase synthesis. 2. Coupling of various building blocks and photolytic cleavage E. A. Akerblom Mol. Diversity, 1999, 4, 53-69.
3.3.14. Solid-phase synthesis of hydroxamic acid based TNF-a convertase inhibitors Barlaam, B.; Koza, P.; Berriot, J. Tetrahedron, 1999, 55(23), 7221-7232.
3.4. Linkers for Alcohols and Amines
3.4.1. Active Carbonate Resins for Solid-Phase Synthesis Through the Anchoring of a Hydroxyl Function. Synthesis of Cyclic and Alcohol Peptides Alsina, J.; Chiva, C. Ortiz, M.; Rabanal, F.; Giralt, E.; Albericio, F. Tetrahedron Lett. 1997, 38, 883-886.
3.4.2. Solid-Supported tert-Alkoxycarbonylation Reagents for Anchoring of Amines during Solid Phase Organic Synthesis Hernandez, A. S.; Hodges, J. C. J. Org. Chem. 1997, 62, 3153-3157.
3.4.3. A New Cleavage Strategy for the Solid-Phase Synthesis of Secondary Amines Conti, P.; Demont, D.; Cals, J.; Ottenheijm, H. C. J.; Leysen, D. Tetrahedron Lett. 1997, 38, 2915-2918.
3.4.4. 5-(4'-Chloromethylphenyl)pentylpolystyrene Resin (CMPP resin). A New Linker Resin for Solid-Phase Organic Synthesis Under Lewis Acidic Conditions Kobayashi, S.; Moriwaki, M. Tetrahedron Lett. 1997, 38, 4251-4254.
3.4.5. Non-Acidic Cleavage of Wang-Derived Ethers From Solid Support: Utilization of a Mixed-Bed Scavenger For DDQ Deegan, T. L.; Gooding, O. W.; Baudart, S.; Porco, J. A. Tetrahedron Lett. 1997, 38, 4973-4976.
3.4.6. A Novel Formamidine Linker for Use in Solid-Phase Synthesis Furth, P. S.; Reitman, M. S.; Cook, A. F. Tetrahedron Lett. 1997, 38, 5403-5406.
3.4.7. Synthesis of Tertiary Amines Using a Polystyrene (REM) Resin Brown, A. R.; Rees, D. C.; Rankovic, Z.; Morphy, J. R. J. Am. Chem. Soc. 1997, 119, 3288-3295.
3.4.8. A New o-Nitrobenzyl Photocleavable Linker for Solid Phase Synthesis Rodebaugh, R.; Fraser-Reid, B.; Geysen, H. M. Tetrahedron Lett. 1997, 38, 7653-7656.
3.4.9. Carbamate Linkers as Latent N-Methylamines in Solid Phase Synthesis Ho, C. Y.; Kukla, M. J. Tetrahedron Lett. 1997, 38, 2799-2802.
3.4.10. Reagents for Combinatorial Organic Synthesis: Preparation and Uses of Rink-Chloride Garigipati, R. S. Tetrahedron Lett. 1997, 38, 6807-6810.
3.4.11. A 2-Silylethanol-base Anomeric Linker for Carbohydrates; Transformation into 1-O-Acyl Derivatives Wallberg, A.; Weigelt, D.; Falk, N.; Magnusson, G. Tetrahedron Lett. 1997, 38, 4285-4286.
3.4.12. A Base Labile Handle for Solid Phase Organic Chemistry Garcia-Eschevarria, C. Tetrahedron Lett. 1997, 38, 8933-8934.
3.4.13. Resin-Immobilised Benzyl and Aryl Vinyl Sulfones: New Versatile Traceless Linkers for Solid-Phase Organic Synthesis Kroll, F. E. K.; Morphy, R.; Rees, D.; Gani, D. Tetrahedron Lett. 1997, 38, 8573-8576.
3.4.14. Polymer-Bound p-Alkoxybenzyl Trichloracetimidates: Reagents for the Protection of Alcohols as Benzyl Ethers on Solid-Phase Hanessian, S.; Xie, F. Tetrahedron Lett. 1998, 39, 733-736.
3.4.15. Exploring Functional and Molecular Diversity with Polymer-Bound p-Alkoxybenzyl Ethers-Scope and Applications of Preparatively Useful Organic Reactions Hanessian, S.; Xie, F. Tetrahedron Lett. 1998, 39,737-740.
3.4.16. Facile Solid Phase Synthesis of Octreotide Analogs Using p-Carboxybenzaldehyde as a Novel Linker to Anchor Fmoc-Threoninol to Solid Phase Resins Wu, Y. T.; Hsieh, H. P.; Wu, C. Y.; Yu, H. M.; Chen. S. T.; Wang, K. T. Tetrahedron Lett. 1998, 39, 1783-1784.
3.4.17. Alcoholysis and Carbonyl Hydrosilylation Reactions using a Polymer-Supported Trialkylsilane Hu, Y.; Porco, J. A. Tetrahedron Lett. 1998, 39, 2711-2714.
3.4.18. A Linker for Solid Phase Carbohydrate Synthesis, Permitting the Introduction of Variable Anomeric Functionality in the Release Step Weigelt, D.; Magnusson, G. Tetrahedron Lett. 1998, 39, 2839-2842.
3.4.19. Simple and Efficient Synthesis of 2-Chlorotritylchloride Resin Orosz, G.; Kiss, L. P. Tetrahedron Lett. 1998, 39, 3241-3242.
3.4.20. Versatile Dde-Based Primary Amine Linkers for Solid Phase Synthesis Chhabra, S. R.; Khan, A. N.; Bycroft, B. W. Tetrahedron Lett. 1998, 39, 3585-3588.
3.4.21. A Novel Linker for the Attachment of Alcohols to Solid Support Bohm, G.; et al Tetrahedron Lett. 1998, 39, 3819-3822.
3.4.22. PhFl Acetic Acid: A New Linker for Solid Phase Organic Synthesis Bleicher, K. H.; Wareing, J. R. Tetrahedron Lett. 1998, 39, 4591-4594.
3.4.23. Beneficial Participation of the Polymer: Improvement in Polymer-Supported Oligosaccharide Synthesis Mehta, S.; Whitfield, D. Tetrahedron Lett. 1998, 39, 5907-5910.
3.4.24. p-Benzyloxybenzylamine (BOBA) Resin. A New Polymer-Supported Amine Used in Solid-Phase Organic Synthesis Kobayashi, S.; Aoki, Y. Tetrahedron Lett. 1998, 39, 7345-7348.
3.4.25. Design and Synthesis of Silyl Ether-Based Linker for Solid-Phase Synthesis of Glycopeptides Nakamura, K.; Hanai, N.; Kanno, M.; Kobayashi, A.; Ohnishi, Y.; Ito, Y.; Nakahara, Y. Tetrahedron Letters, 1999,40, 3, 515-518.
3.4.26. A Novel Linking-Protecting Group Strategy for Solid-Phase Organic Chemistry with Configurationally Stable alpha-[N-(Phenylfluorenyl)]amino Carbonyl Compounds: Synthesis of Enantiopure Norephedrines on Solid Support Gosselin, F.; Van Betsbrugge, J.; Hatam, M.; Lubell, W. D. J. Org. Chem. 1999, 64, 2486-2493.
3.4.27. Triazenes as Robust and Simple Linkers for Amines in Solid-Phase Organic
Synthesis. S. Bräse, J. Köbberling, D. Enders, R. Lazny, M. Wang, S. Brandtner, Tetrahedron Lett. 1999, 40(11), 2105-2108.3.4.28. A Redox-Sensitive Resin Linker for the Solid Phase Synthesis of C-Terminal Modified Peptides Zheng, A.; Shan, D.; Wang, B. J. Org. Chem. 1999, 64, 156-161.
3.4.29. Development of Polymer-Supported Benzotriazole as a Novel Traceless Linker for Solid-Phase Organic Synthesis Schiemann, K.; Showalter, H. D. H. J. Org. Chem. 1999, 64, 4972-4975.
3.4.30. Preparation of Polymer-Bound 1H-Benzotriazole, a New Potential Scaffold for the Compilation of Organic Molecule Libraries Katritzky, A. R.; Belyakov, S. A.; Tymoshenko, D. O. J. Comb. Chem. 1999, 1, 2, 173-176.
3.4.31. Solid-Supported Benzotriazoles: Synthetic Auxiliaries and Traceless Linkers for the Combinatorial Synthesis of Amine Libraries Paio, A.; Zaramella, A.; Ferritto, R.; Conti, N.; Marchioro, C.; Seneci, P. J. Comb. Chem. 1999, 1, 4, 317-325.
3.4.32. Immobilizations of Nucleophiles on Polystyrene Supports Brill, W. K. D.; Schmidt, E., and Tommasi, R. A. Synlett 1998; 8, 906-908.
3.4.33. Application of Polymer Supported Base in Solid Phase Synthesis - Convenient Synthesis of N-Aryl-N'-Benzyl Piperazine Derivatives Yamamoto, Y.; Tanabe, K., and Okonogi, T. Chem. Lett. 1999; (2):103-104.
3.4.34. A Cyclitively Cleavable Linker for Alcohols: Linker Preparation and Cleavage Conditions Xiao, X.-Y.; Nova, M. P.; Czarnik, A. W. J. Combinatorial Chemistry 1999, 1, 5, 379-382.
3.4.35. Dihydropyran-2-carboxylic acid, a novel bifunctional linker for the solid-phase synthesis of peptides containing a C-terminal alcohol Hsieh, H-.P., Wu, Y.T., Chen, S.T., & Wang, K.T. Chem. Commun. 1998, 649-650.
3.4.36. Glycosidation of solid-supported glycosyl donors tethered by a trialkylsilane linker Doi, T.; Sugiki, M.; Yamada, H.; Takahashi, T. Tetrahedron Lett. 1999, 40, 2141-2144.
3.4.37. Use of Quinic Acid as Template in Solid-Phase Combinatorial Synthesis Phoon, C. W.; Abell, C. Journal of Combinatorial Chemistry 1999, 1(6), 485-492.
3.5. Linkers for Hydrocarbons and Other Functional Groups
3.5.1. A TFA-Cleavable Linkage for Solid-Phase Synthesis of Hydroxamic Acids Richter, L. S.; Desai, M. C. Tetrahedron Lett. 1997, 38, 321-322.
3.5.2. Germanium and Silicon Linking Strategies for Traceless Solid-Phase Synthesis Plunkett, M. J.; Ellman, J. A. J. Org. Chem. 1997, 62, 2885-2893.
3.5.3. Traceless Linker: Oxidative Activation and Displacement of a Sulfur-Based Linker Suto, M. J.; Gayo, L. M. Tetrahedron Lett. 1997, 38, 211-214.
3.5.4. The Use of a Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid-Phase Synthesis Routledge, A.; Abell, C.; Balasubramanian, S. Tetrahedron Lett. 1997, 38, 1227-1230.
3.5.5. A Linker for Amidines in Solid Phase Synthesis Roussel, P.; Bradley, M.; Matthews, I.; Kane, P. Tetrahedron Lett. 1997, 38, 4861-4864.
3.5.6. Development of New Linkers for the Formation of Aliphatic C-H Bonds on Polymeric Supports Jung, K. W.; Zhou, X.; Janda, K. D. Tetrahedron Lett. 1997, 53, 6645-6652.
3.5.7. Soluble Polymer Synthesis: An Improved Traceless Linker Methodology for Aliphatic C-H Bond Formation Zhao, X.; Jung, K. W.; Janda, K. D. Tetrahedron Lett. 1997, 38, 977-980.
3.5.8. A Silicon Linker for Direct Loading of Aromatic Compounds to Supports. Traceless Synthesis of Pyridine-Based Tricyclics Woolard, F. X.; Paetsch, J.; Ellman, J. A. J. Org. Chem. 1997, 62, 6102-6103.
3.5.9. A New and Efficient Solid Phase Synthesis of Hydroxamic Acids Ngu, K.; Patel, D. V. J. Org. Chem. 1997, 62, 7088-7089.
3.5.10. A Novel Linkage for the Solid-Phase Synthesis of Hydroxamic Acids Bauer, U.; Ho, W.-B.; Koskinen, A. M. P. Tetrahedron Lett. 1997, 38, 7233-7236.
3.5.11. Facile Prparation of Chloromethylaryl Solid Supports Using Methanesulfonyl Chloride and Hunig's Base Nuigiel, D. A.; Wacker, D. A.; Nemeth, G. A. Tetrahedron Lett. 1997, 38, 5789-5790.
3.5.12. The Use of Thioesters in Solid Phase Organic Synthesis Vlattas, I.; Dellureficio, J.; Dunn, R.; Sytwu, I. I.; Stanton, J. Tetrahedron Lett. 1997, 38, 7321-7324.
3.5.13. A Simple Linker for the Attachment of Aldehydes to the Solid Phase. Application to Solid Phase Synthesis by the Multipin Method Ede, N. J.; Bray, A. M. Tetrahedron Lett. 1997, 38, 7119-7122.
3.5.14. Solid-Phase Synthesis of Arginine-Containing Peptides by Guanidine Attachment to a Sulfonyl Linker Zhong, H. M.; Greco, M. N.; Maryanoff, B. E. J. Org. Chem. 1997, 62, 9326-9330.
3.5.15. Novel Serine-Based Linker for the Solid-Phase Synthesis of Organic Compounds Chou, Y.-L.; Morrissey, M. M.; Mohan, R. Tetrahedron Lett. 1998, 39, 757-760.
3.5.16. A Highly Acid Labile Silicon Linker for Solid Phase Synthesis Hone, N. D.; Davies, S. G.; Devereux, N. J.; Taylor, S. L.; Baxter, A. D. Tetrahedron Lett. 1998, 39, 897-900.
3.5.17. Arylsulfonate Esters in Solid Phase Organic Synthesis. I. Cleavage with Amines, Thiolate, and Imidazole Rueter, J. K.; Nortey, S. O.; Baxter, E. W.; Leo, G. C.; Reitz, A. B. Tetrahedron Lett. 1998, 39, 975-978.
3.5.18. Arylsulfonate Esters in Solid Phase Organic Synthesis. II. Compatibility with Commonly-Used Reaction Conditions Baxter, E. W.; Rueter, J. K.; Nortey, S. O.; Reitz, A. B. Tetrahedron Lett. 1998, 39, 979-982.
3.5.19. Decarboxylation-Based Traceless Linking with Aroyl Acrylic Acids Garibay, P.; Nielsen, J.; Hoeg-Jensen, T. Tetrahedron Lett. 1998, 39, 2207-2210.
3.5.20. Solid Supported Synthesis of Hydroxamic Acids Golebiowski, A.; Klopfenstein, S. Tetrahedron Lett. 1998, 39, 3397-3400.
3.5.21. Novel Phosphate Ester-Linked Resins: The Solid-Phase Generation of Phenyl Phosphate-Containing Compounds for SH2 Inhibition Metcalf, C. A.; Vu, C. B.; Sundaramoorthi, R.; Jacobsen, V. A.; Laborde, E. A.; Green, J.; Green, Y.; Macek, K. J.; Merry, T. J.; Pradeepan, S. G.; Uesugi, M.; Varkhedkar, V. M.; Holt, D. A. Tetrahedron Lett. 1998, 39, 3435-3438.
3.5.22. Reductive Cleavage of Resin Bound Arylsulfonates Jin, S.; Holub, D. P.; Wustrow, D. J. Tetrahedron Lett. 1998, 39, 3651-3654.
3.5.23. Solid Phase Synthesis of Urea Libraries Using a Diversifiable Thiophenoxy Carbonyl Linker Dressman, B. A.; Singh, U.; Kaldor, S. W. Tetrahedron Lett. 1998, 39, 3631-3634.
3.5.24. Novel Polymer-Supported Trialkylsilanes and Their Use in Solid-Phase Organic Synthesis Hu, Y.; Porco, J. A.; Labadie, J. W.; Gooding, O. W.; Trost, B. M. J. Org. Chem. 1998, 63, 4518-4521.
3.5.25. Novel Method for the Loading of Nucleophiles on Multipin Crowns Tommasi, R. A.; Nantermet, P. G.; Shapiro, M. J.; Chin, J.; Brill, W. K.-D.; Ang, K. Tetrahedron Lett. 1998, 39, 5477-5480.
3.5.26. A Practical Method for the Combinatorial Synthesis of Peptide Aldehydes Hall, B. J.; Sutherland, J. D. Tetrahedron Lett. 1998, 39, 6593-6596.
3.5.27. A Facile and Convenient Solid-Phase Procedure for Synthesizing Nucleoside Hydroxamic Acids Khan, S. I.; Grinstaff, M. W. Tetrahedron Lett. 1998, 39, 8031-8034.
3.5.28. Solid-Phase Synthesis of N-Substituted Amidinophenoxy Pyridines as Factor Xa Inhibitors Mohan, R.; Yun, W.; Buckman, B. O.; Liang, A.; Trinh, L.; Morrissey, M. M. Bioorg. Med. Chem. Lett. 1998, 8, 1877-1882.
3.5.29. Novel Polymer-Supported Trialkylsilanes and Their Use in Solid-Phase Organic Synthesis Hu, Y.; Porco, J. A.; Labadie, J. W.; Gooding, O. W. J. Org. Chem. 1998, 63, 4518-4521.
3.5.30. Selenium-Linking Strategy for Traceless Solid-Phase Synthesis: Direct Loading, Aliphatic C-H Bond Formation Upon Cleavage and Reaction Monitoring by Gradient MAS NMR Spectroscopy Ruhland, T.; Andersen, K.; Pedersen, H. J. Org. Chem. 1998, 63, 9204-9211.
3.5.31. Solid-Phase Synthesis of Peptidyl Trifluoromethyl Ketones Poupart, M.-A.; Fazal, G.; Goulet, S.; Mar, L. T. J. Org. Chem. 1999, 64, 1356-1361.
3.5.32. Parallel Synthesis of Aldehydes and Ketone Facilitated by a New Solid-Phase Weinreb Amide Salvino, J. M.; Mervic, M.; Mason, H. J.; Siesow, T.; Teager, D.; Airey, J.; Labaudiniere, R. J. Org. Chem. 1999, 64, 1823-1830.
3.5.33. A Novel, Thioacetal Based Linker for Solid-Phase Synthesis Huwe, C. M.; Kunzer, H. Tetrahedron Letters, 1999, 40, 4, 683-686.
3.5.34. Chromium carbonyl complexes as novel traceless linkers S. E. Gibson, N. J. Hales, M. A. Peplow, Tetrahedron Lett. 1999,40, 7, 1417-1418.
3.5.35. Solid-Phase Synthesis of Hydroxamic Acids Dankwardt, S. M. Synlett 1998; 7, 761-761.
3.5.36. Nucleophilic Substitutions on Multipin(TM) Systems Linked with a Traceless Linker Takahashi, T.; Tomida, S.; Inoue, H., and Doi, T. Synlett 1998; 11, 1261-1263.
3.5.37. Practical Preparation of First Carbon Linked Polymer-Bound 1,3-Diol Chandrasekhar, S.; Padmaja, M. B. Synth. Commun.1998;28(19):3715-3720.
3.5.38. An Oxidation-Labile Traceless Linker for Solid-Phase Synthesis Stieber, F.; Grether, U.; Waldmann, H. Angew. Chem. Int. Ed. 1999, 38(8), 1073-1077.
3.5.39. Efficient Cleavage-Cross-Coupling Strategy for Solid-Phase Synthesis - A Modular Building System for Combinatorial Chemistry Brase, S.; Schroen, M. Angew. Chem. Int. Ed. 1999, 38(8), 1071-1073.
3.5.40. A Surprising Solid-Phase Effect - Development of a Recyclable Traceless Linker System for Reactions on Solid Support Brase, S.; Enders, D.; Kobberling, J., and Avemaria, F. Angew. Chem. Int. Ed. 1998,37, 24, 3413-3415.
3.5.41. Solid Phase Synthesis of C-Terminal Peptide Aldehydes Fehrentz, J. A.; Paris, M.; Heitz, A.; Velek, J.; Winternitz, F.; Martinez, J. J.Org.Chem. 1997,62, 6792-6796.
3.5.42. A new linker for the synthesis of C-terminal peptide alpha-oxo-aldehydes Fruchart, J.-S.; Gras-Masse, H.; Melnyk, O. Tetrahedron Lett. 1999, 40(34), 6225-6228.
3.5.43. Simple silyl linker for the solid phase organic synthesis of aryl-containing molecules Newlander, K.A.; Chenera, B.; Veber, D.F.; Yim, N.C.; Moore, M.L. J. Org. Chem. 1997, 62, 6726-6732.
3.5.44. Solid-phase synthesis of 2-methoxyaniline derivatives by the traceless silicon linker strategy Curtet, S.; Langlois, M. Tetrahedron Lett. 1999, 40(49), 8563-8566.
Chapter 4. Combinatorial Solid Phase Synthesis
4.1. Condensations to Prepare Amides, Esters, Ureas, Imines, Phosphorus, and Other Related Compounds
4.1.1. Solid-Phase Synthesis via N-Terminal Attachment to the 2-Chlorotrityl Resin Hoekstra, W. J.; Greco, M. N.; Yabut, S. C.; Hulshizer, B. L.; Maryanoff, B. E. Tetrahedron Lett. 1997, 38, 2629-2632.
4.1.2 Azido Acids in a Novel Method of Solid-Phase Peptide Synthesis Meldal, M.; Julianok, M. A.; Janson, A. M. Tetrahedron Lett. 1997, 38, 2531-2534.
4.1.3. Solid Phase Synthesis of Ureas of Secondary Amines via Carbamoyl Chloride Wang, G. T.; Chen, Y.; Wang, S.; Sciotti, R.; Sowin, T. Tetrahedron Lett. 1997, 38, 1895-1898.
4.1.4. Solid-Phase Synthesis of Trisubstituted Guanidines Drewry, D. H.; Gerritz, S. W.; Linn, J. A. Tetrahedron Lett. 1997, 38, 3377-3380.
4.1.5. Solid Phase Synthesis of Sulfonamides Using a Carbamate Linker Raju, B.; Kogan, T. P. Tetrahedron Lett. 1997, 38, 19, 3373-3376.
4.1.6. Solid-Phase Synthesis via 5-Oxazolidinones. Ring-Opening Reactions with Amines and Reaction Monitoring by Single-Bead FT-IR Microspectroscopy Marti, R. E.; Yan, B.; Jarosinski, M. A. J. Org. Chem. 1997, 62, 5615-5618.
4.1.7. Solid Phase Synthesis of Substituted Aminosulfonyl Ureas Using a Sulfonylcarbamate Linker Fitzpatrick, L. J.; Rivero, R. A. Tetrahedron Lett. 1997, 38, 7479-7482.
4.1.8. Solid Phase Synthesis of Trisubstituted Guanidines Drewry, D. H.; Gerritz, S. W.; Linn, J. A. Tetrahedron Lett. 1997, 38, 3377-3380.
4.1.9. Solid Phase Synthesis of Cyanoacetamidines: Fast Access to Potential Bioisosteres of Acceptor-Substituted Guanidines Zaragoza, F. Tetrahedron Lett. 1997, 38, 7291-7294.
4.1.10. Solid Phase Synthesis of beta-Peptides via Arndt-Eistert Homologation of Fmoc-Protected Amino Acid Diazoketones Marti, R. E.; Bleicher, K. H.; Bair, K. W. Tetrahedron Lett. 1997, 38, 6145-6148.
4.1.11. Phosphorus-Based Combinatorial Libraries: Use of Amino Acid Derivatives as Synthons Fathi, R.; Patel, R.; Cook, A. F. Molec. Div. 1996, 2, 125-134.
4.1.12. Solid-Phase Synthesis of Disubstituted Guanidines Kearney, P. C.; Fernandez, M.; Flygare, J. A. Tetrahedron Lett. 1998, 39, 2663-2666.
4.1.13. Solid Phase Synthesis of Phosphinopeptoids as Transition State Analog Inhibitors Dorff, P. H.; Chiu, G.; Goldstein, S. W.; Morgan, B. P. Tetrahedron Lett. 1998, 39, 3375-3378.
4.1.14. N-Linked Solid Phase Peptide Synthesis Leger, R.; Yen, R.; She, M. W.; Lee, V. J.; Hecker, S. J. Tetrahedron Lett. 1998, 39,4171-4174.
4.1.15. Solid Phase Synthesis of Combinatorial Libraries Using Anhydrides as Templates Perumattam, J.; Chakravarty, S.; McEnroe, G. A.; Goehring, R. R.; Mavunkel, B.; Suravajjala, S.; Smith, W. W.; Chen, B. Molecular Diversity 1998, 3, 121-128.
4.1.16. Phosgenated p-Nitrophenyl(polystyrene)ketoxime or Phoxime Resin. A New Resin for the Solid-Phase Synthesis of Ureas via Thermolytic Cleavage of Oxime-Carbamates Scialdone, M. A.; Shuey, S. W.; Soper, P.; Hamuro, Y.; Burns, D. M. J. Org. Chem. 1998, 63, 4802-4807.
4.1.17. Preparation of Amides from Acids and Resin Bound Azides: Suppression of Intramolecular Lactam Formation Tang, Z.; Pelletier, J. C. Tetrahedron Lett. 1998, 39, 4773-4776.
4.1.18. Practical Method for the Parallel Synthesis of 2'-Amido-2'-deoxyadenosines Link, A.; Calenbergh, S. van; Herdewijn, P. Tetrahedron Lett. 1998, 39, 5175-5176.
4.1.19. Solid-Phase Synthesis of N,N' Substituted Guanidines Dodd, D. S.; Wallace, O. B. Tetrahedron Lett. 1998, 39, 5701-5704.
4.1.20. Novel Linker for the Solid-Phase Synthesis of Guanidines Josey, J. A.; Tarlton, C. A.; Payne, C. E. Tetrahedron Lett. 1998, 39, 5899-5902.
4.1.21. Transprotection in Solid Phase Peptide Synthesis: Easy Conversion of Fmoc Carbamates into Boc Carbamates Furlan, R. L. E.; Mata, E. G. Tetrahedron Lett. 1998, 39, 6421-6422.
4.1.22. Construction of Combinatorial Chemical Libraries Using a Rapid and Efficient Solid Phase Synthesis Based on a Multicomponent Condensation Reaction Kim, S. W.; Bauer, S. M.; Armstrong, R. W. Tetrahedron Lett. 1998, 39, 6993-6996.
4.1.23. Solid and Solution Phase Combinatorial Synthesis of Ureas Nieuwenhuijzen, J. W.; Conti, P. G. M.; Ottenheijm, H. C. J.; Linders, J. T. M. Tetrahedron Lett. 1998, 39, 7811-7814.
4.1.24. Kinetic Comparison of Amide Formation on Various Cross-Linked Polystyrene Resins Li, W.; Xiao, X.; Czarnik, A. W. J. Combinatorial Chemistry 1999, 1, 2, 127-129.
4.1.25. Solid-Phase Synthesis of Acyclic and Cyclic Amino Acid Derived Urea Peptidomimetics Using Phoxime Resin Hamuro, Y.; Marshall, W. J.; Scialdone, M. A. J. Combinatorial Chemistry 1999, 1, 2, 163-172.
4.1.26. A New Reagent for Solid and Solution Phase Synthesis of Protected
Guanidines From Amines Yong, Y. F.; Kowalski, J. A.; Thoen, J. C.; Lipton, M. A.Tetrahedron Lett., 40, 1, 53-56.4.1.27. A Simple Procedure for the Solid Phase Synthesis of Unsymmetrically Functionalised Diamides from Symmetric Diacids Wahhab, A.; Leban, J. Tetrahedron Lett., 40, 2, 235-238.
4.1.28. Preparation and Use of N-Hydroxysuccinimidyl Active Ester Resins Adamczyk, M.; Fishpaugh, J. R.; Mattingly, P. G. Tetrahedron Lett. 1999, 40, 463-466.
4.1.29. Soluble Polymer-Supported Synthesis of N,N-di(BOC)-Protected Guanidines Shey, J. Y. and Sun, C. M. Synlett 1998, 12, 1423-1425.
4.1.30. Solid Support-Bound Synthesis of Polyfunctional Unsymmetrical Ureas Maurer, K. W. and Kenyon, G. L. Bioorg. Chem. 1997;25(5-6):277-281.
4.1.31. Solid phase synthesis of aryl and heteroaryl amines using the Curtius rearrangement S. Sunami, T. Sagara, M. Ohkubo, H. Morishima Hiemstra, Tetrahedron Lett. 1999, 40(9), 1721-1724.
4.1.32. Solid-phase synthesis of N,N'-unsymmetrically substituted ureas: application to the synthesis of carbaza peptides D. Limal, V. Semetey, P. Dalbon, M. Jolivet, J.-P. Briand, Tetrahedron Lett.1999,40(14), 2749-2752.
4.1.33. Microwave-assisted solid-phase Ugi four-component condensations A. M. L. Hoel, J. Nielsen, Tetrahedron Lett. 1999, 40(20), 3941-3944.
4.1.34. A traceless linker approach to the solid phase synthesis of substituted guanidines utilizing a novel acyl isothiocyanate resin L. J. Wilson, S. R. Klopfenstein, M. Li, Tetrahedron Lett. 1999,40(21), 3999-4002.
4.1.35. Solid phase urea synthesis: an efficient and direct conversion of Fmoc-protected amines to ureas P. Y. Chong, P. A. Petillo, Tetrahedron Lett. 1999, 40(24), 4501-4504.
4.1.36. Novel Solid-Phase Synthesis of Azapeptides and Azapeptoides via Fmoc-Strategy and Its Application in the Synthesis of RGD-Mimetics C. Gibson, S. L. Goodman, D. Hahn, G. Hölzemann, H. Kessler J. Org. Chem. 1999, 64(20), 7388-7394.
4.1.37. Convergent Synthesis of Dolastatin 15 by Solid Phase Coupling of an N-Methylamino Acid Akaji, K., Hayashi, Y., Kiso, Y., Kuriyama, N. J. Org. Chem. 1999, 64(2), 405-411.
4.1.38. Solid phase synthesis of aza peptides using an automatic synthesizer Ahn, I-A, Kim, S. W., Ro S. Mol. Diversity 1999, (4), 23-24.
4.1.39. N-Fmoc-Aminooxy-2-chlorotrityl polystyrene resin: A facile solid-phase methodology for the synthesis of hydroxamic acids Mellor, S.L., McGuire, C., Chan, W.C. Tetrahedron Lett. 1997, 38, 3311-3314.
4.1.40. A novel synthesis of diethyl 1-aminoarylmethylphosphonates on the surface of alumina Sardarian, A.R., & Kaboudin, B. Tetrahedron Lett. 1997, 38, 2543-2546.
4.1.41. Solid-phase synthesis of tri-functionalised, alpha-substituted carbamoylmethyl-homocysteine compounds, their release from the resin and subsequent intramolecular cyclisation to give novel 1,3,3-trisubstituted succinimides Girdwood, J.A., & Shute, R.E. Chem. Commun. 1997, 2307-2308.
4.1.42. Impurity Annihilation - A Strategy for Solution-Phase Combinatorial Chemistry with Minimal Purification Barrett, A. G. M.; Smith, M. L., and Zecri, F. J. Chem. Comm. 1998; 21, 2317-2318.
4.1.43. Solid phase synthesis of guanidines Robinson, S.; Roskamp, E.J. Tetrahedron 1997, 53, 6697-6705.
4.1.44. Automated synthesis and purification of amides: Exploitation of automated solid phase extraction in organic synthesis Lawrence, R.M.; Biller, S.A.; Fryszman, O.M.; Poss, M.A. Synthesis-Stuttgart 1997, 553-558.
4.2. Carbon-Carbon Bond Formation on Solid Support
4.2.1. Solid-Phase Synthesis of Peptide Mimetics with (E)-Alkene Amide Bond Replacements Derived from Alkenylaziridines Wipf, P.; Henninger, T. C. J. Org. Chem. 1997, 62, 1586-1587.
4.2.2. A New Approach to the Solid-Phase Suzuki Coupling Reaction Piettre, S. R.; Baltzer, S. Tetrahedron Lett. 1997, 38, 1197-1200.
4.2.3. Combinatorial Synthesis of C(2), C(3)-Disubstituted 3-Hydroxypropionamides Utilizing Baylis-Hilman Reactions on Solid Support Prien, O.; Rolfing, K.; Thiel, M.; Kunzer, H. Synlett 1997, 3, 325-326.
4.2.4. Solid Phase Synthesis of Ketones from Esters Wallace, O. B. Tetrahedron Lett. 1997, 38, 4939-4942.
4.2.5. The Solid Phase Synthesis of Disubstituted Unnatural Amino Acids and Peptides (di-UPS) Scott, W. L.; Zhou, C.; Fang, Z.; O'Donnell, M. J. Tetrahedron Lett. 1997, 38, 3695-3698.
4.2.6. Solid Phase Synthesis of Unnatural Amino Acids using Unactivated Alkyl Halides O'Donnell, M. J.; Lugar, C. W.; Pottorf, R. S.; Zhou, C.; Scott, W. L.; Cwi, C. L. Tetrahedron Lett. 1997, 38, 3695-3698.
4.2.7. Tandem UPS: Sequential Mono- and Dialkylation of Resin-Bound Glycine via Automated Synthesis Griffith, D. L.; O'Donnell, M. J.; Pottorf, R. S.; Scott, W. L.; Porco, J. A. Tetrahedron Lett. 1997, 38, 8821-8824.
4.2.8. Solid-Phase Synthesis of 4-Arylazetidine-2-ones via Suzuki and Heck Cross-Coupling Reactions Ruhland, B.; Bombrun, A.; Gallop, M. A. J. Org. Chem. 1997, 62, 7820-7826.
4.2.9. Asymmetric Crotylation Reactions on Solid Support: Synthesis of Stereochemically Well-Defined Polypropionate-Like Subunits Panek, J. S.; Zhu, B. J. Am. Chem. Soc. 1997, 119, 12022-12023.
4.2.10. A New Attachment/Cleavage Strategy: Polymer Bound Allylic Sulfones in a Solid-Phase Route to Trisubstituted Olefins Halm, C.; Evarts, J.; Kurth, M. J. Tetrahedron Lett. 1997, 38, 7709-7712.
4.2.11. Solid Phase Heterocyclic Synthesis via Ring Closing Metathesis: Traceless Linking and Cyclative Cleavage Through a Carbon-Carbon Double Bond Piscopio, A. D.; Miller, J. F.; Koch, K. Tetrahedron Lett. 1997, 38, 7143-7146.
4.2.12. Ring Opening Cross-Metathesis on Solid Support Cuny, G. D.; Cao, J.; Hauske, J. R. Tetrahedron Lett. 1997, 38, 5237-5240.
4.2.13. New Multi-Coupling Benzylic Zinc Reagents for the Preparation of Flexible Aromatic Compounds Rottlander, M.; Knochel, P. Tetrahedron Lett. 1997, 38, 1749-1752.
4.2.14. Macrocyclization on Solid Support using Heck Reaction Akaji, K.; Kiso, Y. Tetrahedron Lett. 1997, 38, 5185-5188.
4.2.15. Synthesis of Primary Amines via Nucleophilic Addition of Organicmetallic Reagents to Aldimines on Solid Support Katritzky, A. R.; Xie, L.; Zhang, G.; Griffith, M.; Watson, K.; Kiely, J. S. Tetrahedron Lett. 1997, 38, 7011-7014.
4.2.16. Solid-Phase Synthesis of Novel Amino-Ether Derivatives Furth, P. S.; Reitman, M. S.; Gentles, R.; Cook, A. F. Tetrahedron Lett. 1997, 38, 6643-6646.
4.2.17. Synthesis of Chrial alpha-Substituted beta-Hydroxy Acid Derivatives on Solid Support Purandare, A. V.; Natarajan, S. Tetrahedron Lett. 1997, 38, 8777-8780.
4.2.18. Solid Phase Synthesis of 2-Aminobutadienes Using a Piperazine Linker Hird, N. W.; Irie, K.; Nagai, K. Tetrahedron Lett. 1997, 38, 7111-7114.
4.2.19. Synthesis of 3,4,5-Trisubstituted Cyclohexanones by Cycloaddition to Solid Phase 2-Aminobutadienes Crawshaw, M.; Hird, N. W.; Irie, K.; Nagai, K. Tetrahedron Lett. 1997, 38, 7115-7118.
4.2.20. Transformation of Resin-Bound Pyridinium Ylides: I. A Stereoselective Synthesis of 2,2,3-Trisubstituted Cyclopropanecarboxylates Vo, N. H.; Eyermann, C. J.; Hodge, C. N. Tetrahedron Lett. 1997, 38, 7951-7954.
4.2.21. Intermolecular Free Radical Reactions on Solid Support. Allylation of Esters Sibi, M. P.; Chandramouli, S. V. Tetrahedron Lett. 1997, 38, 8929-8932.
4.2.22. Mannich Reactions of Resin-Bound Substrates: 2. A Versatile Three-Component Solid-Phase Organic Synthesis Methodology McNally, J. J.; Youngman, M. A.; Dax, S. L. Tetrahedron Lett. 1998, 39, 967-970.
4.2.23. Solid-Phase Preparation of Dienes Blaskovich, M. A.; Kahn, M. J. Org. Chem. 1998, 63, 1119-1125.
4.2.24. Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Synthesis of a (dl)-Muscone Library Nicolaou, K. C.; Pastor, J.; Winssinger, N.; Murphy, F. J. Am. Chem. Soc. 1998, 120, 5132-5133.
4.2.25. Solid Phase Aldol and Conjugate Addition Reactions Using Evans' Oxazolidinone Chiral Auxiliary Phoon, C. W.; Abell, C. Tetrahedron Lett. 1998, 39, 2655-2658.
4.2.26. Solid-Phase Functionalization of Heterocycles by Direct Lithiation Li, Z.; Ganesan, A. Synlett 1998, 405.
4.2.27. Ruthenium-Catalyzed Yne-Ene Cross Metathesis Binding to Solid Support and Cleavage by Pd(0)-Catalysis Schurer, S. C.; Blechert, S. Synlett1998, 166-168.
4.2.28. Ruthenium-Catalyzed Yne-Ene Cross Metathesis Immobilization of Functionalized Alkynes Schuster, M.; Blechert, S. Tetrahedron Lett. 1998, 39, 2295-2298.
4.2.29. Knoevenagel Condensation of Unsymmetrical Malonamic Esters and Malonates on a Solid Support Hamper, B. C.; Kolodziej, S. A.; Scates, A. M. Tetrahedron Lett. 1998, 39, 2047-2050.
4.2.30. Solid-Phase Synthesis of Substituted Glutamic Acid Derivatives via Michael Addition Reactions Dominguez, E.; O'Donnell, M. J.; Scott, W. L. Tetrahedron Lett. 1998, 39, 2167-2170.
4.2.31. Solid-Phase C-Acylation of Active Methylene Compounds Sim, M. M.; Lee, C. L.; Ganesan, A. Tetrahedron Lett. 1998, 39, 2195-2198.
4.2.32. SmI2-Mediated Sequential Radical Cyclization/Anionic Capture of Aryl Iodides on Solid Support Du, X.; Armstrong, R. W. Tetrahedron Lett. 1998, 39, 2281-2284.
4.2.33. Substituted Sulfonamides via a Three Component Reaction on Solid Support Richter, H.; Jung, G. Tetrahedron Lett. 1998, 39, 2729-2730.
4.2.34. Copper-Catalyzed Coupling of Polymer Bound Iodide with Organostannanes Kang, S.-K.; Kim, J.-S.; Yoon, S.-K.; Lim, K.-H.; Yoon, S. S. Tetrahedron Lett. 1998, 39, 3011-3012.
4.2.35. The Solid Phase Synthesis of Complex Propargylamines Using the Combination of Sonogashira and Mannich Reactions Dyatkin, A. B.; Rivero, R. A. Tetrahedron Lett. 1998, 39, 3647-3650.
4.2.36. The Stille Cross Coupling Reactions on Solid Support. Link to Solution Phase Directed ortho Metalation. An Ester Linker Approach to Styryl, Biaryl and Heterobiaryl Carboxylic Acids Chamoin, S.; Houldsworth, S.; Snieckus, V. Tetrahedron Lett. 1998, 39, 4175-4178.
4.2.37. The Suzuki-Miyaura Cross Coupling Reactions on Solid Support. Link to Solution Phase Directed ortho Metalation. The Leznoff Acetal Linker Approach to Biaryl and Heterobiaryl Aldehydes Chamoin, S.; Houldsworth, S.; Kruse, C. G.; Bakker, W. I.; Snieckus, V. Tetrahedron Lett. 1998, 39, 4179-4182.
4.2.38. Diels-Alder Reaction on Solid Supports Using Polymer-Bound Oxazolidinones Winkler, J. D.; McCoull, W. Tetrahedron Lett. 1998, 39, 4935-4936.
4.2.39. Directed ortho-Lithiation on Solid Phase Havez, S.; Begtrup, M.; Vedso, P.; Anderson, K.; Ruhland, T. J. Org. Chem. 1998, 63, 7418-7420.
4.2.40. Solid-Phase Horner-Emmons Synthesis of Olefins Salvino, J. M.; Kiesow, T. J.; Darnbrough, S.; Labaudiniere, R. J. Combinatorial Chemistry 1999, 1, 2, 134-139.
4.2.41. Intermolecular Conjugate Addition of Alkyl Radicals on Solid Phase Zhu, X.; Ganesan, A. J. Combinatorial Chemistry 1999, 1, 2, 157-162.
4.2.42. New Chemoselective Metalating Agents for Solid-Phase Synthesis Kondo, Y.; Komine, T.; Fujinami, M.; Uchiyama, M.; Sakamoto, T. J. Combinatorial Chemistry 1999, 1, 1, 123-126.
4.2.43. Palladium-Catalyzed Coupling of Functionalized Bromoarenes to a Polystyrene-Bound Aryl Tributylstannane Brody, M. S.; Finn, M. G. Tetrahedron Lett. 1999, 40, 3, 415-418.
4.2.44. Novel Synthesis of alpha-Amino Acid Derivatives through Triethylborane-Induced Solid-Phase Radical Reactions Miyabe, H.; Fujishima, Y.; Naito, T. J. Org. Chem. 1999, 64, 2174-2175.
4.2.45. Pd-Mediated C-C and Cs Bond Formation with Olefins and Acetylenes on Solid Support - A Scope and Limitations Study Berteina, S.; Wendeborn, S.; Brill, W. K. D., and Demesmaeker, A. Synlett. 1998;6, 676-678.
4.2.46. Radical and Palladium-Mediated Cyclizations of Ortho-Iodo Benzyl Enamines - Application to Solid-Phase Synthesis Berteina, S.; Wendeborn, S., and Demesmaeker, A. Synlett 1998; 11, 1231-1233.
4.2.47. Synthesis of homoallylic amines via N-acyliminium ion reactions on solid support W. J. N. Meester, F. P. J. T. Rutjes, P. H. H. Hermkens, H. Hiemstra, Tetrahedron Lett. 1999, 40(8), 1601-1604.
4.2.48. Allylindium and allylboronic acid pinacolate: mild reagents for the allylation of resin-bound aldehydes. Application to the solid-phase synthesis of hydroxypropylamines C. L. Cavallaro, T. Herpin, B. F. McGuinness, Y. C. Shimshock, R. E. Dolle, Tetrahedron Lett. 1999, 40(14), 2711-2714.
4.2.49. Preparation of new functionalized hydrocarbon linkers via Suzuki cross coupling reaction C. Vanier, A. Wagner, C. Mioskowski, Tetrahedron Lett. 1999, 40(23), 4335-4338.
4.2.50. Solid-phase synthesis of amino acids by radical addition to a dehydroalanine derivative A.-M. Yim, Y. Vidal, P. Viallefont, J. Martinez, Tetrahedron Lett. 1999, 40(24), 4535-4538.
4.2.51. Stereocontrolled solution and solid phase enolate alkylations and hydroxylations generation of three and four contiguous stereogenic carbon atoms in acyclic systems S. Hanessian, J. Ma, W. Wang, Tetrahedron Lett. 1999, 40(25), 4631-4634.
4.2.52. Solid-Phase Synthesis of -Keto Esters via Sequential Baylis-Hillman and Heck Reactions Kulkarni, B. A., Ganesan, A., J. Comb. Chem.; 1999;1(5); 373-378.
4.2.53. A Novel Chiral Pentamine Ligand for Enantioselective -Alkylation of Acyclic Lithium Amide Enolates. Optimization of Chiral Ligands for Asymmetric Reactions Using Solid-Phase Organic Synthesis Matsuo, J.-i., Odashima, K., Kobayashi, S. Org. Lett. 1999; 1(2); 345-348.
4.2.54. Solid-phase synthesis of unnatural alpha-amino acid derivatives using a resin-bound glycine cation equivalent M. J. O'Donnell, F. Delgado, M. D. Drew, R. S. Pottorf, C. Zhou, W. L. Scott Tetrahedron Lett.1999,40(32), 5831-5836.
4.2.55. Palladium-catalyzed three component coupling on solid support Y. Wang, T.-N. Huang Tetrahedron Lett. 1999, 40(32), 5837-5840.
4.2.56. Two Methods for the Preparation of 2-Cyclohexenones from Resin-Bound 1,3-Cyclohexanedione Fraley, M. E.; Rubino, R. S. Tetrahedron Lett. 1997, 38, 3365-3368.
4.2.57. Solid-Phase Synthesis on Planar Supports Lebl, M.Biopolymers (Peptide Science) 1998, 47, 397-404.
4.2.58. Ring-Closing Metathesis on Solid Support - Elaboration of a Cyclization/Cleavage Strategy
Towards Unsaturated Alpha-Ester-Substituted N-Heterocycles Veerman, J. J. N.; Vanmaarseveen, J. H.; Visser, G. M.; Kruse, C. G.; Schoemaker, H. E.; Hiemstra, H., and Rutjes, F. P. J. T. Eur. J. Org.Chem. 1998; (11) 2583-2589
4.2.59. Resin type can have important effects on solid phase asymmetric reactions alkylation reactions Burgess, K., & Lim, D. J. Chem. Soc. Chem. Commun. 1997, 785-786.
4.2.60. Ruthenium catalyzed cross metathesis binding of functionalized olefins to polystyrene resin via a novel allylsilyl linker suitable for electrophilic cleavage Schuster, M., Lukas, N., & Blechert, S. J. Chem. Soc. Chem. Commun. 1997, 823-824.
4.2.61. Chameleon Catches in Combinatorial Chemistry - Tebbe Olefination of Polymer-Supported Esters and the Synthesis of Amines, Cyclohexanones, Enones, Methyl Ketones and Thiazoles Ball, C. P.; Barrett, A. G. M.; Commercon, A.; Compere, D.; Kuhn, C.; Roberts, R. S.; Smith, M. L., and Venier, O. Chem. Comm. 1998, (18) 2019-2020.
4.2.62. Palladium-catalyzed allylic substitution on solid support Tietze, L.F., Hippe, T., & Steinmetz, A. Chem. Commun. 1998, 793-794.
4.2.63. Development of Chloromethylated SynPhase Crowns and Their Use in Pd(0) Mediated Cross-Coupling Reactions Wendeborn, S., Beaudegnies, R., Ang, K.H., Maeji, N. J. Biotech. Bioeng. (Comb.Chem.) 1998, 61, 89-92.
4.2.64. Synthesis of benzofuran derivatives on solid support via SmI2-mediated radical cyclization Du, X., Armstrong, R. J. Org. Chem. 1997, 62, 5678-5679.
4.2.65. Resin-to-resin acyl- and aminoacyl-transfer reactions using oxime supports Hamuro, Y., Scialdone, M. A., DeGrado, W. F. J. Amer. Chem. Soc. 1999, 121, 1636-1644.
4.2.66. An approach to controlled oligomerization via iterative Diels-Alder cycloadditions on solid supports Winkler, J.D., Kwak, Y.S. J. Org. Chem. 1998, 63, 8634-8635.
4.2.67. Preparation of Highly Functionalized Grignard-Reagents by an Iodine-Magnesium Exchange-Reaction and Its Application in Solid-Phase Synthesis Boymond, L.; Rottlander, M.; Cahiez, G.; Knochel, P. Angew. Chem. Int. Ed. 1998; 37(12) 1701-1703.
4.2.68. Palladium-catalyzed carbon-carbon bond formation on a solid phase utilizing hypervalent iodonium salts Kang, S.K.; Yoon, S.K.; Lim, K.H.; Son, H.J.; Baik, T.G. Syn. Commun. 1998, 28, 3645-3655.
4.2.69. Polymer-supported acetylide addition to hexa-2,4-dienal Blaskovich, M.A.; Kahn, M. Synthesis-Stuttgart 1998, 965-966.
4.2.70. Mild N-Dealkylation of Tertiary, Benzylic Amines with Acid Chlorides: Applications to Solid Phase Chemistry Miller, M. W.; Vice, S. F.; McCombie, S. W. Tetrahedron Lett. 1998, 39, 3429-3432.
4.2.71. Solid phase synthesis of cyclopropenes Cano, M.; Camps, F.; Joglar, J. Tetrahedron Lett. 1998, 39, 9819-9822.
4.2.72. Ring closing metathesis in organic synthesis: Evolution of a high speed, solid phase method for the preparation of -turn mimetics Piscopio, A. D.; Miller, J. F.; Koch, K. Tetrahedron 1999, 55(27), 8189-8198.
4.2.73. Solution-phase ring opening cross-metathesis of bicyclic alkenes with styrene derivatives and its application to "resin capture" solid-phase synthesis Cuny, G. D.; Cao, J.; Sidhu, A.; Hauske, J. R. Tetrahedron 1999, 55(27), 8169 -8178.
4.2.74. Chiral lithium amides on solid support: synthesis and applications in enantioselective deprotonation of cyclic ketones Majewski, M.; Ulaczyk, A.; Wang, F. Tetrahedron Lett. 1999, 40(50), 8755.
4.2.75. Enantioselective solid-phase synthesis of a-amino acid derivatives O'Donnell, M. J.; Delgado, F.; Pottorf, R. S. Tetrahedron, 1999, 55(20), 6347-6362.
4.2.76. Solid phase approach to muscone synthesis: Rh(I)-catalyzed hydroformylation of a 1,1-disubstituted alkene on the multipinTM system Takahashi, T.; Ebata, S.; Doi, T. Tetrahedron Lett. 1998, 39, 1369-1372.
4.2.77. Soluble polymer-supported synthesis of arylpiperazines Pan, P.-C.; Sun, C.-M. Tetrahedron Lett. 1998, 39, 9505-9508.
4.2.78. Highly stereoselective preparation of 3,3-disubstituted acrylates on polyethylene glycol Blettner, C.G.; Konig, W.A.; Stenzel, W.; Schotten, T. Tetrahedron Lett. 1999, 40, 2101-2102.
4.2.79. An easily prepared, air and moisture stable, resin-bound palladium catalyst for Suzuki cross-coupling reactions Zhang, T. Y.; Allen, M. J. Tetrahedron Lett. 1999, 40(32), 5813-5816.
4.2.80. Palladium-catalyzed three component coupling on solid support Wang, Y.; Huang, T.-N. Tetrahedron Lett. 1999, 40(32), 5837-5840.
4.2.81. Solid-Phase Intermolecular Radical Reactions 1. Sulfonyl Radical Addition to Isolated Alkens and Alkynes Caddick, S.; Hamza, D.; Wadman, S. N. Tetrahedron Lett. 1999, 40, 7285-7288.
4.2.82. Exploring the Scope of Poly(ethylene glycol) (PEG) as a Soluble Polymer Matrix for the Stille Cross-Coupling Reaction Sieber, F.; Wentworth, P. Jr.; Janda, K. D. Journal of Combinatorial Chemistry 1999, 1(6), 540-546.
4.2.83. Parallel Synthesis of Prostaglandin E1 Analogues Dragoli, D. R; Thompson, L. A. O'Brien, J.; Ellman, J. A. Journal of Combinatorial Chemistry; 1999, 1(6), 534-539.
4.3. Mitsunobu Reactions on Solid Support
4.3.1. Solid-Phase Synthesis of Smale Molecule Libraries using Double Combinatorial Chemistry Nielsen, J.; Jensen, F. R. Tetrahedron Lett. 1997, 38, 2011-2014.
4.3.2. Solid Phase Synthesis of Fmoc N-Methyl Amino Acids: Application of the Fukuyama Amine Synthesis Yang, L.; Chiu, K. Tetrahedron Lett. 1997, 38, 7307-7310.
4.3.3. Amino Acid Side Chain Attachment Approach and Its Application to the Synthesis of Tyrosine-Containing Cyclic Peptides Cabrele, C.; Langer, M.; Beck-Sickinger, A. G. J. Org. Chem. 1999, 64, 12, 4353-4361.
4.3.4. A novel solid support for derivatization and subsequent N-alkylation of secondary amines: Preparation of N-alkylated 5- and 6-alkoxy-1,2,3,4-tetrahydroisoquinolines via Mitsunobu reaction Heinonen, P., Lonnberg, H. Tetrahedron Lett. 1997, 38, 8569-8572.
4.4. Substitution and Addition Reactions on Solid Support
4.4.1. Site-Selective N-Methylation of Peptides on Solid Support Miller, S. C.; Scanlan, T. S. J. Am. Chem. Soc. 1997, 119, 2301-2302.
4.4.2. Rapid and Efficient Solid Phase Synthesis of Cyclic Peptides with Endocyclic Biaryl Ether Bonds Burgess, K.; Lim, D.; Bois-Choussy, M.; Zhu, J. Tetrahedron Lett. 1997, 38, 3345-3348.
4.4.3. Mannich Reactions of a Resin-Bound Terminal Alkyne Youngman, M. A.; Dax, S. L. Tetrahedron Lett. 1997, 38, 6347-6350.
4.4.4. The Solid-Phase Combinatorial Synthesis of beta-Thioketones Chen, C.; Randall, L. A. A.; Miller, R. B.; Jones, A. D.; Kurth, M. J. Tetrahedron 1997, 53, 6595-6609.
4.4.5. Solid Phase Synthesis of beta-Peptoids: N-Substituted beta-Aminopropionic Acid Oligomers Hamper, B. C.; Kolodziej, S. A.; Scates, A. M.; Smith, R. G.; Cortez, E. J. Org. Chem. 1998, 63, 708-718.
4.4.6. Solid Phase Synthesis of Unsymmetrical Secondary Amines-Application to the Synthesis of Arylethanolamines and Arylpropanolamines Purandare, A. V.; Poss, M. A. Tetrahedron Lett. 1998, 39, 935-938.
4.4.7. oNBS-SPPS: A New Method for Solid-Phase Peptide Synthesis Miller, S. C.; Scanlan, T. S. J. Am. Chem. Soc. 1997, 120, 2690-2691.
4.4.8. Site-Specific N-Alkylation of Peptides on Solid Phase Reichwein, J. F.; Liskamp, R. M. J. Tetrahedron Lett. 1998, 39, 1243-1246.
4.4.9. Solid Phase Synthesis of Functional Biaryl Ethers: Versatile Scaffolds for Combinatorial Chemistry Wijkmans, J. C. H. M.; Culshaw, A. J.; Baxter, A. D. Molecular Diversity 1998, 3, 117-120.
4.4.10. Composition and Purity of Combinatorial Aryl Ether Collection Analyzed by Electrospray Mass Spectrometry Haap, W. J.; Metzger, J. W.; Kempter, C.; Jung, G. Molecular Diversity 1998, 3, 29-41.
4.4.11. Rapid Solid Phase Synthesis of alpha-Amino Acids Barbaste, M.; Rolland-Fulcrand, V.; Roumestant, M.-L.; Viallefont, P.; Martinez, J. Tetrahedron Lett. 1998, 39, 6287-6290.
4.4.12. A Simple and Efficient Method for the Syntheses of Thioether Cyclic Peptides Yu, L.; Lai, Y.; Wade, J. V.; Coutts, S. M. Tetrahedron Lett. 1998, 39, 6633-6636.
4.4.13. First Aromatic Electrophilic Iodination Reaction on the Solid-Phase: Iodination of Bioactive Peptides Arsequell, G.; Espuna, G.; Valencia, G.; Barluenga, J.; Carlon, R. P.; Gonzalez, J. M. Tetrahedron Lett. 1998, 39, 7393-7396.
4.4.14. Composition and Purity of Combinatorial Aryl Ether Collections Analyzed by Electrospray Mass Spectrometry (Williamson etherification) Haap, W. J.; Metzger, J. W.; Kempter, C.; Jung, G. Molecular Diversity 1997, 3, 29-41.
4.4.15. Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti Cosquer, A.; Pichereau, V.; Le Mee, D.; Le Roch, M.; Renault, J.; Carboni, B.; Uriac, P.; Bernard, T. Bioorganic & Medicinal Chemistry Letters, 1999 9, 1, 49-54.
4.4.16. Solution and Solid-Phase p-Alkoxybenzylation of Alcohols Under Neutral Conditions Hanessian, S.; Huynh, H. K. Tetrahedron Letters, 1999, 40, 4, 671-674.
4.4.17. Solid supported aryl/heteroaryl C-N cross-coupling reactions A. P. Combs, S. Saubern, M. Rafalski, P. Y. S. Lam Hiemstra, Tetrahedron Lett. 1999, 40, 9, 1623-1626.
4.4.18. Model Study for Preparation of Asymmetric N,N'-Disubstituted Piperazine Library - Efficient Synthesis of Aryl Piperazine and Benzyl Piperazine Derivatives on the Solid Support Yamamoto, Y.; Ajito, K., and Ohtsuka, Y. Chem. Lett. 1998; (5):379-380.
4.4.19. Efficient Solid-Phase Synthesis of Beta-Aminosubstituted Piperidinols Rosse, G.; Ouertani, F.; Schroder, H. J. Combinatorial Chemistry 1999, 1, 5, 397-401.
4.4.20. One Pot Synthesis of Unsymmetrically Functionalized Polyamines by a Solid Phase Strategy Starting from their Symmetrical Polyamine-Counterparts Byk G.; Frederic, M.; Scherman, D Tetrahedron Lett. 1997, (38), 3219-3222.
4.4.21. A Visual Tagging Process for Mix and Sort Combinatorial Chemistry Guiles, J. W.; Lanter, C. L.; Rivero, R. A. Angew. Chem. Int. Ed. 1998; 37(7) 926-928.
4.4.22. Application of polymer-supported electrophilic reagents for the 1,2-functionalization of glycals Kirschning, A.; Jesberger, M.; Monenschein, H. Tetrahedron Lett. 1999, 40(51), 8999-9002.
4.4.23. Evaluation of Gaseous Hydrogen Fluoride as a Convenient Reagent for Parallel Cleavage from the Solid Support Lebl, M.; Pires, J.; Poncar, P.; Pokorny, V Journal of Combinatorial Chemistry; 1999, 1(6), 474-479.
4.4.24. Synthesis and Use of a 2-(Trimethylsilyl)ethoxymethyl-Based Linker in Solid-Phase Organic Chemistry Koot, W.-J.Journal of Combinatorial Chemistry 1999, 1(6), 467-473.
4.5. Oxidations on Solid Support
4.5.1. Ozone: a Versatile Reagent for Solid Phase Synthesis Sylvain, C. Wagner, A.; Mioskowski, C. Tetrahedron Lett. 1997, 38, 1043-1044.
4.5.2. Synthesis of Functionalized gamma- and delta-Lactones via Polymer-Bound Epoxides Hetet, C. L.; David, M.; Carreaux, F.; Carboni, B.; Sauleau, A. Tetrahedron Lett. 1997, 38, 5153-5156.
4.5.3. Solid-Phase Synthesis of Tyrosine Peptide Aldehdyes. Analogues of (S)-MAPI Page, P.; Bradley, M.; Walters, I.; Teague, S. J. Org. Chem. 1999, 64, 794-799.
4.5.4. Solid phase synthesis of aryl and aryl amines using the Curtius rearrangement S. Sunami, T. Sagara, M. Ohkubo, H. Morishima Hiemstra, Tetrahedron Lett. 1999, 40, 9, 1721-1724.
4.5.5. Selective solid-phase iodination of phenolic groups with bis(pyridine)iodonium (I) tetrafluoroborate G. Arsequell, G. Espuña, G. Valencia, J. Barluenga, R. Pérez Carlón, J. M. González Tetrahedron Lett., 1999, 40, 7279-7282.
4.5.6. Polyaniline Supported Cobalt(II) Catalyst: Oxidation of Alkenes with Molecular Oxygen Das, B. C.; Iqbal, J. Tetrahedron Lett., 1997, 38, 1235-1238.
4.5.7. High-throughput purification of solution-phase periodinane mediated oxidation reactions utilizing a novel thiosulfate resin Parlow, J. J.;. Case, B. L.; South, M. S. Tetrahedron, 1999, 55(22), 6785-6796.
4.6. Reductions on Solid Support
4.6.1. Alkylation of Rink's Amide Linker on Polystyrene Resin: A Reductive Amination Approach to Modified Amine-Linkers for the Solid Phase Synthesis of N-Substituted Amide Derivatives Brown, E. G.; Nuss, J. M. Tetrahedron Lett. 1997, 38, 8457-8460.
4.6.2. Potassium Borohydride Reductions of Immobilised Ketosteroids Briggs, J. C.; Hodge, P.; Zhengpu, Z. Tetrahedron 1997, 53, 3943-3956.
4.6.3. Solid Phase Synthesis of N-Carboxy Alkyl-Containing Peptides Derived from Enantiopure Alpha-Keto-Beta-Amino Acids Fernandez-Garcia, C.; Prager, K.; McKervey, M. A.; Walker, B.; Williams, C. H. Bioorg. Med. Chem. Lett. 1998, 8, 433-436.
4.6.4. Reductions of Olefins on Solid Support Using Diimide Lacombe, P.; Castagner, B.; Gareau, Y.; Ruel, R. Tetrahedron Lett. 1998, 39, 6785-6786.
4.6.5. Titanium Mediated Reductive Amination on Solid Support: Extending the Utility of the 4-Hydroxy-Thiophenol Linker Breitenbucher, J. G.; Hui, H. C. Tetrahedron Lett. 1998, 39, 8207-8210.
4.6.6. Efficiencies of Reductive Amination Reactions on Different Solid Supports Bui, C. T.; Rasoul, F. A.; Ercole, F.; Pham, Y.; Maeji, N. J. Tetrahedron Lett. 1998, 39, 9279-9282.
4.6.7. A New Method for the Mild and Selective Reduction of Aryl Nitro Groups on Solid Support Hari, A.; Miller, B. L. Tetrahedron Lett. 1998, 40, 245-248.
4.6.8. Parallel Solid Phase Synthesis of Tetrasubstituted Diethylenetriamines via Selective Amide Alkylation and Exhaustive Reduction of N-acylated Dipeptides Nefzi, A.; Ostresh, J. M.; Houghten, R. A. Tetrahedron, 1999, 55, 2, 335-344.
4.6.9. Development of a Reductive Alkylation Method Using p-Benzyloxybenzylamine (BOBA) Resin for the Synthesis of N-Alkylated Amides Aoki, Y.; Kobayashi, S. J. Combinatorial Chemistry 1999, 1, 5, 371-372.
4.6.10. Generation of secondary alkyl amines on solid support by borane reduction: Application to the parallel synthesis of PPAR ligands Brown, P.J.; Hurley, K.P.; Stuart, L.W.; Willson, T.M. Synthesis-Stuttgart 1997, 778-782.
4.7. Preparation of Heterocyclic Compounds
4.7.1. A Solid-Phase Combinatorial Method for the Synthesis of Novel 5- and 6-Membered Ring Lactams Short, K. M.; Mjalli, A. M. M. Tetrahedron Lett. 1997, 38, 359-362.
4.7.2. Combinatorial Synthesis of 2,9-Substituted Purines Gray, N. S.; Kwon, S.; Schultz, P. G. Tetrahedron Lett. 1997, 38, 1161-1164.
4.7.3. Construction of Indole and Benzofuran Systems on Solid-Phase via Palladium Mediated Cyclizations Zhang, H-C.; Maryanoff, B. E. J. Org. Chem. 1997, 62, 1804-1809.
4.7.4. Synthesis of Trisubstituted Indoles on the Solid Phase via Palladium-Mediated Heteroannulation of Internal Alkynes Zhang, H-C.; Brumfield, K. K.; Maryanoff, B. E. Tetrahedron Lett. 1997, 38, 2439-2442.
4.7.5. Solid Phase Synthesis of 2-Substituted Benzofurans via the Palladium-Catalysed Heteroannulation of Acetylenes Fagnola, M. C.; Candiani, I.; Visentin, G.; Cabri, W.; Zarini, F.; Mongelli, N.; Bedeschi, A. Tetrahedron Lett. 1997, 38, 2311-2314.
4.7.6. Solid-Phase Synthesis of Indoles Using the Palladium-Catalysed Coupling of Alkynes with Iodoaniline Derivatives Fancelli, D.; Fagnola, M. C.; Severino, D.; Bedeschi, A. Tetrahedron Lett. 1997, 38,2307-2310.
4.7.7. A General and Efficient Solid Phase Synthesis of Quinazoline-2,4-diones Gordeev, M. F.; Hui, H. C.; Gordon, E. M.; Patel, D. V. Tetrahedron Lett. 1997, 38, 1729-1732.
4.7.8. Combinatorial Synthesis and Biological Evaluation of Library of Small-Molecule Ser/Thr-Protein Phosphatase Inhibitors Wipf, P.; Cunningham, A.; Rice, R. L.; Lazo, J. S. Bioorg. Med. Chem. 1997, 5, 165-177.
4.7.10. Combinatorial Synthesis of Heterocycles: Solid Phase Synthesis of 2-Arylquinoline-4-carboxylic Acid Derivatives Gopalsamy, A.; Pallai, P. V. Tetrahedron Lett. 1997, 38, 907-910.
4.7.11. Solid Phase Synthesis of Heterocyclic Compounds from Linear Peptides: Cyclic Ureas and Thioureas Nefzi, A.; Ostresh, J. M.; Meyer, J-P.; Houghten, R. A. Tetrahedron Lett. 1997, 38, 931-934.
4.7.12. Solid Phase Synthesis of Biphenyltetrazole Derivatives Yoo, S.; Seo, J.; Yi, K.; Gong, Y. Tetrahedron Lett., 1997, 38, 1227-1230.
4.7.13. An Investigation into Solid-Phase Radical Chemistry-Synthesis of Furan Rings Routledge, A.; Abell, C.; Balasubramanian, S. Synlett 1997, 1, 61-62.
4.7.14. Solid Phase Synthesis of Heterocyclic Compounds from Linear Peptides: Cyclic Ureas and Thioureas Nefzi, A.; Ostresh, J. M.; Meyer, J-P.; Houghten, R. A. Tetrahedron Lett. 1997, 38, 931-934.
4.7.15. Solid Phase Synthesis of Hydantoin Library Using a Novel Cyclization and Traceless Cleavage Step Kim, S. W.; Ahn, S. Y.; Koh, J. S.; Lee, J. H.; Ro, S.; Cho, H. Y. Tetrahedron Lett. 1997, 38, 4603-4606.
4.7.16. Solid Phase Synthesis of 3,4-Disubstituted-7-carbamoyl-1,2,3,4-tetrahydroquinoxalin-2-ones Lee, J.; Murray, W. V.; Rivero, R. A. J. Org. Chem. 1997, 62, 3874-3879.
4.7.17. Two Methods for the Preparation of 2-Cyclohexenones from Resin-Bound 1,3-Cyclohexanedione Fraley, M. E.; Rubino, R. S. Tetrahedron Lett. 1997, 38, 3365-3368.
4.7.18. Synthesis of 4-Amino-3,4-dihydro-2(1H)-Quinolinones via beta-Lactam Intermediates on The Solid Phase Pei, Y.; Houghten, R. A.; Kiely, J. S. Tetrahedron Lett. 1997, 38, 3349-3352.
4.7.19. Rapid and Efficient Solid Phase Syntheses of Cyclic Peptides with Endocyclic Biaryl Ether Bonds Burgess, K.; Lim, D.; Bois-Choussy, M.; Zhu, J. Tetrahedron Lett. 1997, 38, 3345-3348.
4.7.20. Solid Phase Synthesis of 2,3-Dihydro-4-pyridones: Reaction of Danishefsky's Diene with Polymer-Bound Imines Wang, Y.; Wilson, S. R. Tetrahedron Lett. 1997, 38, 4021-4024.
4.7.21. Solid Phase Synthesis of 1,2,4,7-Tetrasubstituted Perhydro-1,4-diazepine-2,5-diones Nefzi, A.; Ostresh, J. M.; Houghten, R. A. Tetrahedron Lett. 1997, 38, 4943-4946.
4.7.22. Resin-Bound Isothiocyanates and Their Synthetic Equivalents as Intermediates for the Solid-Phase Synthesis of Substituted Thiophenes Stephensen, H.; Zaragoza, F. J. Org. Chem. 1997, 62, 6096-6097.
4.7.23. Cyclobutenedione Derivatives on Solid Support: Toward Multiple Core Structure Libraries Tempest, P. A.; Armstrong, R. W. J. Am. Chem. Soc. 1997, 119, 7607-7608.
4.7.24. Solid-Phase Synthesis of 1,4-Benzodiazepine-2,5-diones. Library Preparation and Demonstration of Synthesis Generality Boojamra, C. G.; Burow, K. M.; Thompson, L. A.; Ellman, J. A. J. Org. Chem. 1997, 62, 1240-1256.
4.7.25. The Synthesis of a 1680 Member 1,4-Benzodiazepine Library Bunin, B. A.; Plunkett, M. J.; Ellman, J. A.; Bray, A. M. New J. Chem. 1997, 21, 125-130.
4.7.26. Solid Phase Synthesis of Benzimidazoles Phillips, G. B.; Wei, G. P. Tetrahedron Lett. 1997, 37, 4887-4890.
4.7.27. Solid-Phase Synthesis of Benzoxazoles via Mitsunobu Reaction Wang, F.; Hauske, J. R. Tetrahedron Lett. 1997, 38, 6529-6532.
4.7.28. Solid-Phase Synthesis of Pyrrolidines via 2-Azaallyl Anion Cycloadditions with Alkenes Pearson, W. H.; Clark, R. B. Tetrahedron Lett. 1997, 38, 7669-7672.
4.7.29. Synthesis of Epothilones A and B in Solid and Solution Phase Nicolaou, K. C.; Winssinger, N.; Pastor, J.; Ninkovic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E. Nature, 1997, 387, 268-272.
4.7.30. Encoded Combinatorial Chemistry: Synthesis and Screening of a Library of Highly Functionalized Pyrrolidines Maclean, D.; Schuller, J. R.; Murphy, M. M.; Ni, Z.-J.; Gordon, E. M.; Gallop, M. A. Proc. Natl. Acad. Sci. USA 1997, 94, 2805-2810.
4.7.31. Beta-Lactams on Solid Support: Mild and Efficient Removal of Penicillin Derivatives from Merrifield Resin using Aluminum Chloride Mata, E. G. Tetrahedron Lett. 1997, 38, 6335-6338.
4.7.32. Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support Arumugam, V.; Routledge, A.; Abell, C.; Balasubramanian, S. Tetrahedron Lett. 1997, 38, 6473-6476.
4.7.33. The Solid Phase Synthesis of Tri-Substituted Indoles Ellingboe, J. W.; Collini, M. D. Tetrahedron Lett. 1997, 38, 7963-7966.
4.7.34. Solid Support Synthesis of Tetrahydroquinolines via the Grieco Three Component Condensation Kiselyov, A. S.; Armstrong, R. W. Tetrahedron Lett. 1997, 38, 6163-6166.
4.7.35. Solid Phase Synthesis of Quinazolinones Mayer, J. P.; Lewis, G. S.; Curtis, M. J.; Zhang, J. Tetrahedron Lett. 1997, 38, 8445-8448.
4.7.36. Synthetic Design for Combinatorial Chemistry. Solution and Polymer-Supported Synthesis of Polycyclic Lactams by Intramolecular Cyclization of Azomethine Ylides Marx, M. A.; Grillot, A.-L.; Louer, C. T.; Beaver, K. A.; Bartlett, P. A. J. Am. Chem. Soc. 1997, 119, 6153-6167.
4.7.37. Solid-Phase Synthesis of Diverse Tetrahydro-1,4-Benzodiazepine-2-ones Bhalay, G.; Blaney, P.; Palmer, V. H.; Baxter, A. D. Tetrahedron Lett. 1997, 38, 8375-8378.
4.7.38. A Chemoselective Rhodium(II) Mediated Solid Phase 1,3-Dipolar Cycloaddition and its Application to a Thermally Self-Cleaving Furan Scaffold Whitehouse, D. L.; Nelson, K. H.; Savinov, S. N.; Austin, D. J. Tetrahedron Lett. 1997, 38, 7139-7142.
4.7.39. "Traceless" Solid-Phase Synthesis of Furans via 1,3-Dipolar Cycloaddition Reactions of Isomuchnones Gowravaram, M. R.; Gallop, M. A. Tetrahedron Lett. 1997, 38, 6973-6976.
4.7.40. Solid Phase Synthesis of Fused Bicyclic Amino Acid Derivatives via Intramolecular Pauson-Khand Cyclization: Versatile Scaffolds for Combinatorial Chemistry Bolton, G. L.; Hodges, J. C.; Rubin, J. R. Tetrahedron 1997, 53,6611-6634.
4.7.41. Polymer-Supported Synthesis as a Tool for Improving Chemoselectivity: Pauson-Khand Reaction Spitzer, J. L.; Kurth, M. J.; Schore, N. E.; Najdi, S. D. Tetrahedron 1997, 53, 6791-6808.
4.7.42. Exploitation of the Ugi 4CC Reaction: Preparation of Small Molecule Combinatorial Libraries via Solid Phase Short, K. M.; Ching, B. W.; Mjalli, A. M. M. Tetrahedron 1997, 53, 6653-6679.
4.7.43. Solid-Phase Synthesis of beta-Sultams Gordeev, M. F.; Gordon, E. M.; Patel, D. V. J. Org. Chem. 1997, 62, 8177-8181.
4.7.44. Solid-Phase Synthesis of 2-Aminothiazoles Kearney, P. C.; Fernandez, M.; Flygare, J. A. J. Org. Chem. 1997, 62, 196-200.
4.7.45. Synthesis of Dihydropyridone Scaffolds on solid Support: Resin Activation/Capture Approach/REACAP Technology Chen, C.; McDonald, I. A.; Munoz, B. Tetrahedron Lett. 1998, 38, 217-220.
4.7.46. A Novel and Efficient Approach for the Combinatorial Synthesis of Structurally Diverse Pyrimidines on Solid Support Obrecht, D.; Abrecht, C.; Grieder, A.; Villalgordo, J. M. Helv. Chem. Acta. 1997, 80, 65-72.
4.7.47. Solid-Phase Synthesis of 3,4-Dihydroquinazoline Wang, F.; Hauske, J. R. Tetrahedron Lett. 1997, 38, 8651-8654.
4.7.48. Solid Phase Synthesis of 5-Aminopyrazoles and Derivatives Watson, S. P.; Wilson, R. D.; Judd, D. B.; Richards, S. A. Tetrahedron Lett. 1997, 38, 9065-9068.
4.7.49. Xanthines as a Scaffold for Molecular Diversity Heizmann, G.; Eberle, A. N. Molec. Div. 1996, 2, 171-174.
4.7.50. Solid-Phase Synthesis of Polymer-Bound beta-Ketoesters and Their Application in the Synthesis of Structurally Diverse Pyrazolones Tietze, L. F.; Steinmetz, A.; Balkenhohl, F. Bioorg. Med. Chem. Lett. 1997, 7, 1303-1306.
4.7.51. The Solid Phase Synthesis of Trisubstituted 1,4-Diazabicyclo[4.3.0]nonan-2-one Scaffolds: On Bead Monitoring of Heterocycle Forming Reactions Using N-15 NMR Swayze, E. E. Tetrahedron Lett. 1997, 38, 8643-8646.
4.7.52. Key Intermediates in Combinatorial Chemistry: Access to Various Heterocycles from alpha,beta-Unsaturated Ketones on the Solid Phase Marzinzik, A. L.; Felder, E. R. J. Org. Chem. 1998, 63, 723-727.
4.7.53. Solid-Phase Synthesis of Isoxazolines Cheng, J. F.; Mjalli, A. M. M. Tetrahedron Lett. 1998, 39, 939-942.
4.7.54. Solid Phase Synthesis of Tropane Derivatives Jonsson, D.; Molin, H.; Unden, A. Tetrahedron Lett. 1998, 39, 1059-1062.
4.7.55. A Peptoid Based Synthesis of Di- and Tri-Substituted 2-Oxopiperazines on Solid Support Goff, D. A. Tetrahedron Lett. 1998, 39, 1473-1476.
4.7.56. The Synthesis of 2-Imidazolidones on Solid Support by Tandem Aminoacylation/Michael Addition Goff, D. A. Tetrahedron Lett. 1998, 39, 1477-1480.
4.7.57. Generation of a Piperazine-2-carboxamide Library: A Practical Application of the Phenol-Sulfide React and Release Linker Breitenbucher, J. G.; Johnson, C. R.; Haight, M.; Phelan, J. C. Tetrahedron Lett. 1998, 39, 1295-1298.
4.7.58. Synthesis of Diverse Tetrahydro-beta-Carboline-3-Carboxamides and -2,3-Bis-lactams On a Versatile 4-Hydroxythiophenol-Linked Solid Support Fantauzzi, P. P.; Yager, K. M. Tetrahedron Lett. 1998, 39, 1291-1294.
4.7.59. Solid-Phase Synthesis of Diverse E- and F-Series Prostaglandins Thompson, L. A.; Moore, F. L.; Moon, Y-C.; Ellman, J. A. J. Org. Chem. 1998, 63, 2066-2067.
4.7.60. Solid-Supported Synthesis of Imidazoles: A Strategy for Direct Resin-Attachment to the Imidazole Core Bilodeau, M. T.; Cunningham, A. M. J. Org. Chem. 1998, 63, 2800-2801
4.7.61. Carbohydrate-Based Small-Molecule Scaffolds for the Construction of Universal Pharmacophore Mapping Libraries Sofia, M. J.; Hunter, R.; Chan, T. Y.; Vaughan, A.; Dulina, R.; Wang, H.; Gange, D. J. Org. Chem. 1998, 63, 2802-2803.
4.7.62. Solid-Phase Synthesis: Intramolecular Azomethine Ylide Cycladdition (-Proline) and Carbanilide Cyclization (-Hydantoin) Reactions Gong, Y.-D.; Najdi, S.; Olmstead, M. M.; Kurth, M. J. J. Org. Chem. 1998, 63, 3081-3086.
4.7.63. Solid-Phase Synthesis of Heterocycles Containing an 1-Acyl-3-oxopiperazine Skeleton Vojkovsky, T.; Weichsel, A.; Patek, M. J. Org. Chem. 1998, 63, 3162-3163.
4.7.64. Single Bead IR Monitoring of a Novel Benzimidazole Synthesis Sun, Q.; Yan, B. Bioorg. Med. Chem. Lett. 1998, 8, 361-364.
4.7.65. Facile Substitution of Resin-Bound Indoles via the Mannich Reaction Zhang, H. C.; Brumfield, K. K.; Jaroskova, L.; Maryanoff, B. E. Tetrahedron Lett. 1998, 39, 4449-4452.
4.7.66. Solid-Phase Synthesis of Tetramic Acids Kulkarni, B. A.; Ganesan, A. Tetrahedron Lett. 1998, 39, 4369-4372.
4.7.67. One Pot Solid Phase Synthesis of Isoxazolines Shankar, B. B.; Yang, D. Y.; Girton, S.; Ganguly, A. K. Tetrahedron Lett. 1998, 39, 2447-2448.
4.7.68. Solid-Phase Synthesis of Diketopiperazines, Useful Scaffolds for Combinatorial Chemistry Fresno, M. D.; Alsina, J.; Royo, M.; Barany, G.; Albericio, F. Tetrahedron Lett. 1998, 39, 2639-2642.
4.7.69. Oligosaccharide Synthesis on Controlled-Pore Glass as Solid Phase Material Heckel, A.; Mross, E.; Jung, K. H.; Rademann, J.; Schmidt, R. R. Synlett 1998, 171-173.
4.7.70. A Second Generation Solid Phase Approach to Freidinger Lactams: Application of Fukuyama's Amine Synthesis and Cyclative Release via Ring Closing Metathesis Piscopio, A. D.; Miller, J. F.; Koch, K. Tetrahedron Lett. 1998, 39, 2667-2670.
4.7.71. Cyclic Oligocarbamates Warrass, R.; Wiesmuller, K.-H.; Jung, G. Tetrahedron Lett. 1998, 39, 2715-2716.
4.7.72. Solid Phase Synthesis of 5-Aminopyrazoles and Derivatives Part II Wilson, R. D.; Watson, S. P.; Richards, S. A. Tetrahedron Lett. 1998, 39, 2827-2830.
4.7.73. Solid Phase Synthesis of 2,4-Disubstituted Pyridine and Tetrahydropyridine Derivatives: Resin Activation/Capture Approach/REACAP Technology Chen, C.; Munoz, B. Tetrahedron Lett. 1998, 39, 3401-3404.
4.7.74. High Pressure Promoted Tandem [4+2]/[3+2] Cycloadditions On The Solid Phase Kuster, G. J.; Scheeren, H. W. Tetrahedron Lett. 1998, 39,3613-3616.
4.7.75. Parallel Synthesis of 3-Aminoimidazo[1,2-a]pyridines and pyrazines by a New Three-Component Condensation Blackburn, C.; Guan, B.; Fleming, P.; Shiosaki, K.; Tsai, S. Tetrahedron Lett. 1998, 39, 3635-3638.
4.7.76. Solid Phase Synthesis of 2,4,5-Trisubstituted Thiomorpholin-3-ones Nefzi, A.; Giulianotti, M.; Houghten, R. A. Tetrahedron Lett. 1998, 39, 3635-3638.
4.7.77. Solid Phase Synthesis of a 1,3,5-Trisubstituted Pyridinium Salt Library Lago, M. A.; Nguyen, T. T.; Bhatnagar, P. Tetrahedron Lett. 1998, 39, 3885-3888.
4.7.78. Total Synthesis of a Naturally Occurring Prostaglandin F-2alpha on a Non-Cross-Linked Polystyrene Support Chen, S.; Janda, K. D. Tetrahedron Lett. 1998, 39, 3943-3946.
4.7.79. Solid-Supported Syntheses of 3-Thio-1,2,4-Triazoles Wilson, M. W.; Hernandez, A. S.; Calvet, A. P.; Hodges, J. C. Molecular Diversity1998, 3, 95-112.
4.7.80. Solid Phase Synthesis of Benzamidine and Butylamine-Derived Hydantoin Libraries Kim, S. W.; Koh, J. S.; Lee, E. J.; Ro, S. Molecular Diversity 1998, 3, 129-132.
4.7.81. Combinatorial Approaches to Pharmacophoric Heterocycles: A Solid-Phase Synthesis of 3,1-Benzoxazine-4-Ones Gordeev, M. F. Biotechnology and Bioengineering (Combinatorial Chemistry) 1998, 61, 1, 13-16.
4.7.82. Solid-Phase Synthesis of Substituted Tetramic Acids Matthews, J.; Rivero, R. A. J. Org. Chem. 1998, 63, 4808-4810.
4.7.83. Solid Phase Synthesis of Fumitremorgin, Verruculogen and Tryprostatin Analogs based on a Cyclization/Cleavage Strategy Loevezijn, A. van; Maarseveen, J. H. van; Stegman, K.; Visser, G. M.; Koomen, G.-J. Tetrahedron Lett. 1998, 39, 4737-4740.
4.7.84. Solid-Phase Synthesis of Substituted Quinoline and Isoquinoline Derivatives Using Heterocyclic N-oxide Chemistry Hoemann, M. Z.; Melikian-Badalian, A.; Kumaravel, G.; Hauske, J. R. Tetrahedron Lett. 1998, 39, 4749-4752.
4.7.85. Solid Phase Synthesis of 1-Aminohydantoin Libraries Wilson, L. J.; Li, M.; Portlock, D. E. Tetrahedron Lett. 1998, 39, 5135-5138.
4.7.86. A Three-Component Solid-Phase Synthesis of 3-Aminoimidazo[1,2-a]azines Blackburn, C. Tetrahedron Lett. 1998, 39, 5469-5472.
4.7.87. Efficient Robotic Synthesis. Multi-component Preparation of a Tricyclic Template by Solid Phase Tsunge Reaction Bicknell, A. J.; Hird, N. W.; Readshaw, S. A. Tetrahedron Lett. 1998, 39, 5869-5872.
4.7.88. Solid-Phase Synthesis of 3-Amino-2-pyrazolines Lyngso, L. O.; Nielsen, J. Tetrahedron Lett. 1998, 39, 5845-5848.
4.7.89. Application of Radical Chemistry to Solid Support Synthesis Berteina, S.; Mesmaeker, A. D. Tetrahedron Lett. 1998, 39, 5759-5762.
4.7.90. Solid-Phase Combinatorial Synthesis of 4-hydroxyquinolin-2(1H)-ones Sim, M. M.; Lee, C. L.; Ganesan, A. Tetrahedron Lett. 1998, 39, 6399-6402.
4.7.91. Solid-Phase Synthesis of Benzimidazoles Mayer, J. P.; Lewis, G. S.; McGee, C.; Bankaitis-Davis, D. Tetrahedron Lett. 1998, 39, 6655-6658.
4.7.92. Combinatorial Chemistry. Use of an Intramolecular Ruthenium Catalyzed Olefin/Alkyne Metathesis Reaction in Tandem With a Diels-Alder Cycloaddition Reaction to Construct Functionalized Hexahydroisoindoles Heerding, D. A.; Takata, D. T.; Kwon, C.; Huffman, W. F.; Samanen J. Tetrahedron Lett. 1998, 39, 6815-6818.
4.7.93. Solid Phase Synthesis of N-Acyl-2-Substituted-Dihydro-4-Pyridone: Resin Activation/Capture Approach/REACAP Technology Chen, C.; Munoz, B. Tetrahedron Lett. 1998, 39, 6781-6784.
4.7.94. Ration Design and Synthesis of Unsaturated 2,5-Dioxopiperazine Derivatives as Potential Protein Tyrosine Kinase Inhibitors Li. W.-R.; Peng, S.-Z. Tetrahedron Lett. 1998, 39, 7373-7376.
4.7.95. A Practical Solid Phase Synthesis of Quinazoline-2,4-diones Shao, H.; Colucci, M.; Tong, S.; Zhang, H.; Castelhano, A. L. Tetrahedron Lett. 1998, 39, 7235-7238.
4.7.96. Novel Safety-Catch Linker and its Application with a Ugi/De-Boc/Cyclization (UDC) Strategy to access Carboxylic Acids, 1,4-Benodiazepines, Diketopiperazines, Ketopiperazines, and Dihydroquinoxalinones Hulme, C.; Peng, J.; Morton, G.; Salvino, J. M.; Herpin, T.; Labaudiniere, R. Tetrahedron Lett. 1998, 39, 7227-7230.
4.7.97. An Efficient High-Speed Synthetic Route to Amino-Substituted Thiazolidinone Libraries Munson, M.C.; Cook, A. W.; Josey, J. A.; Rao, C. Tetrahedron Lett. 1998, 39, 7223-7226.
4.7.98. Polymer-bound 4-Benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a Tool for the Solid-Phase Synthesis of Substituted Piperidin-4-one Derivatives Barco, A.; Benetti, S.; De Risi, C.; Marchetti, P.; Pollini, G. P.; Zanirato, V. Tetrahedron Lett. 1998, 39, 7591-7594.
4.7.99. Combinatorial Modification of 2-Ketopiperazine with Solid Phase C-Alkylation and N-Acylations Zhu, Z.; Mckittrick, B. Tetrahedron Lett. 1998, 39, 7479-7482.
4.7.100. Solid-Phase Synthesis of Substituted 1-Phenyl-2aminomethyl-benzimidazoles and 1-Phenyl-2-thiomethyl-benzimidazoles Tumelty, D.; Schwarz, M. K.; Needels, M. C. Tetrahedron Lett. 1998, 39, 7467-7470.
4.7.101. Polymer-Supported Preparation of Substituted Phenols: A New Example of Simultaneous Cyclization-Cleavage Reaction on Solid Phase Katritzky, A. R.; Belyakov, S. A.; Fang, Y.; Kiely, J. S. Tetrahedron Lett. 1998, 39, 8051-8054.
4.7.102. Traceless Solid Phase Synthesis of 2,3-Disubstituted Indoles Smith, A. L.; Stevenson, G. I.; Swain, C. J.; Castro, J. L. Tetrahedron Lett. 1998, 39, 8317-8320.
4.7.103. Solid-Phase Synthesis of Pyrroles from Enaminones and Nitroalkenes Trautwein, A. W.; Jung, G. Tetrahedron Lett. 1998, 39, 8263-8266.
4.7.104. Efficient Synthesis of Substituted Oxopiperazines From Amino Acids Mohamed, N.; Bhatt, U.; Just, G. Tetrahedron Lett. 1998, 39, 8213-8216.
4.7.105. Efficient Solid Phase Synthesis of 3,5-Disubstituted Hydantoins Nefzi, A.; Ostresh, J. M.; Giulianotti, M.; Houghten, R. A. Tetrahedron Lett. 1998, 39, 8199-8202.
4.7.106. Solid-Phase Synthesis of a Library of Piperazinediones and Diazepinediones via Kaiser Oxime Resin Smith, R. A.; Bobko, M. A.; Lee, W. Bioorg. Med. Chem. Lett. 1998, 8, 2369-2374.
4.7.107. Novel Safety-Catch Linker and its Application with a Ugi/De-BOC/Cyclization (UDC) Strategy to Access Carboxylic acids, 1,4-Benzodiazepines, Diketopiperazines, Ketopiperazines and Dihydroquinoxalinones Hulme, C.; Peng, J.; Morton, G.; Salvino, J. M.; Herpin, T.; Labaudiniere, R. Tetrahedron Lett. 1998, 39, 7227-7230.
4.7.108. Heterocyclic Mixture-Based Combinatorial Libraries: Synthesis and Analysis of Composition (3,4-dihydro-2-(1H)-quinolinones) Kiely, J. S.; Pei, Y. Trends in Drug Research II 1998, 29, 147-156.
4.7.109. SN-Ar Cyclization to Form Cyclic Peptidomimetics of beta-Turns Feng, Y.; Wang, Z.; Jin, S.; Burgess, K. J. Am. Chem. Soc. 1998, 120, 10768-10769.
4.7.110. Combinatorial Chemistry of Hydantoins Boeijen, A.; Kruijitzer, J. A. W.; Liskamp, R. M. J. Bioorg. Med. Chem. Lett. 1998, 8, 2375-2380.
4.7.111. Diastereoselective Solid-Phase Synthesis of Novel Hydantoin- and Isoxazoline-Containing Heterocycles Park, K.-H.; Olmstead, M. M.; Kurth, M. J. J. Org. Chem. 1998, 63, 6579-6585.
4.7.112. Stereoselective Synthesis of over Two Million Compounds Having Structual Features Both Reminiscent of Natural Products and Compatible with Miniatureized Cell-Based Assays Tam, D. S.; Foley, M. A.; Shair, M. D.; Schreiber, S. L. J. Am. Chem. Soc. 1998, 120, 8565-8566.
4.7.113. Synthesis of Hydantoins via N,N'-Ureas Derived From Polymer-Bound Amino Acids Bauser, M.; Winter, M.; Valenti, C. A.; Wiesmuller, K.-H.; Jung, G. Molecular Diversity 1998, 3, 257-260.
4.7.114. Lanthanide Triflate-Catalyzed 1,3-Dipolar Cycloaddition Reactions of Polymer-Supported Nitrones with Alkenes for the Preparation of Diverse 2-Isoxazoline Derivatives Tetrahedron Lett. 1998, 39, 9211-9214.
4.7.115. Immobilized Aldehydes and Olefins in the Solid-Phase Synthesis of Tetrahydroquinolines via a Three Component Condensation Kiselyov, A. S.; Smith, L.; Virgilio, A.; Armstrong, R. Tetrahedron 1998, 54, 7987-7996.
4.7.116. Polymer Bound 3-hydroxy-2-methylidenepropionic Acids. A Template for Multiple Core Structure Libraries Richter, H.; Walk, T.; Holtzel, A.; Jung, G. J. Org. Chem. 1999, 64, 1362-1365.
4.7.117. Parallel Synthesis of 1,2,3-Thiadiazoles Employing a "Catch and Release" Strategy Hu, Y.; Baudart, S.; Porco, J. A. J. Org. Chem. 1999, 64, 1049-1051.
4.7.118. A Solid Phase Approach to Substituted Pyrimidines and Their Conversion into Condensed Heterocycles for Potential Use in Combinatorial Chemistry Srivastava, S. K.; Haq, W.; Chauhan, P. M. S. Combinatorial Chemistry & High Throughput Screening 1999, 2, 33-37.
4.7.119. Solid-Phase Synthesis of Substituted Benzazepines via Intramolecular Heck Cyclization Bolton, G. L.; Hodges, J. C. J. Combinatorial Chemistry1999, 1, 2, 130-133.
4.7.120. Solid-Phase Synthesis of Cyclic Imides Barn, D. R.; Morphy, J. R. J. Combinatorial Chemistry 1999, 1, 2, 151-156.
4.7.121. Solid-Phase Synthesis of 2,4,6-Trisubstituted Pyridines Chiu, C.; Tang, Z.; Ellingboe, J. W. J. Combinatorial Chemsitry 1999, 1, 1, 73-77.
4.7.122. Solid-phase amino-zinc-enolate cyclization for the synthesis of 3-substituted prolines
Karoyan, P. ; Triolo, A.; Nannicini, R.; Giannotti, D.; Altamura, M.; Chassaing, G.; Perrotta E. Tetrahedron Letters, 1999, 40, 1, 71-74.4.7.123. <